{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:16:27Z","timestamp":1790972187125,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,12,17]],"date-time":"2008-12-17T00:00:00Z","timestamp":1229472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:p> <jats:bold>\n            <jats:italic>Introduction:<\/jats:italic>\n          <\/jats:bold> Pulmonary vein isolation (PVI) is an established treatment for paroxysmal atrial fibrillation (AF). The ablation of complex fractionated atrial electrograms (CFAE) has emerged as a novel treatment approach. We sought to evaluate the additional effect of CFAE ablation to PVI in paroxysmal AF.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Methods and Results:<\/jats:italic>\n          <\/jats:bold> Ninety\u2010eight patients with paroxysmal AF (57 \u00b1 10 years, 74 male) were randomized to the PVI (n = 48) or PVI + CFAE group (n = 50). After PVI, CFAE ablation was performed in patients with inducible AF in the PVI + CFAE group. The primary endpoint was combined objective (7\u2010day Holter ECG) and subjective (symptoms) freedom of atrial tachyarrhythmia 3 months after ablation. Long\u2010term follow\u2010up (19 \u00b1 8 months) was available in 94 of 98 patients. CFAE ablation was performed in 30 of 50 patients of the PVI + CFAE group. After 3 months, 36 of 48 patients (75%) in the PVI group and 38 of 50 patients (76%) in the PVI + CFAE group were in stable sinus rhythm (P = NS). During long\u2010term follow\u2010up (19 \u00b1 8 months), 34 of 46 patients (74%) in the PVI group and 40 of 48 patients (83%) in the PVI + CFAE group were in sinus rhythm (P = 0.08). In a subgroup analysis, a significantly better long\u2010term outcome was achieved if inducible AF after PVI had been treated by additional CFAE ablation as compared with PVI only (sinus rhythm in 25\/28 patients; 89% vs 22\/30 patients 73%; P = 0.003).<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Conclusion:<\/jats:italic>\n          <\/jats:bold> In the intention\u2010to\u2010treat analysis, additional CFAE ablation did not improve the success rate of PVI in patients with paroxysmal AF. However, during long\u2010term follow\u2010up, patients with still inducible AF after PVI seemed to profit from additional CFAE ablation.<\/jats:p>","DOI":"10.1111\/j.1540-8167.2008.01379.x","type":"journal-article","created":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T07:49:20Z","timestamp":1229672960000},"page":"514-521","source":"Crossref","is-referenced-by-count":68,"title":["Does Electrogram Guided Substrate Ablation Add to the Success of Pulmonary Vein Isolation in Patients with Paroxysmal Atrial Fibrillation? A Prospective, Randomized Study"],"prefix":"10.1111","volume":"20","author":[{"given":"ISABEL","family":"DEISENHOFER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HEIDI","family":"ESTNER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TILKO","family":"REENTS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STEPHANIE","family":"FICHTNER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AXEL","family":"BAUER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JINJIN","family":"WU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTOF","family":"KOLB","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BERNHARD","family":"ZRENNER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CLAUS","family":"SCHMITT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GABRIELE","family":"HESSLING","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4,21]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2007.04.005"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl176"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(64)90371-0"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00177-2"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199809033391003"},{"key":"e_1_2_8_7_2","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1161\/01.CIR.102.20.2463","article-title":"Electrophysiological breakthroughs from the left atrium to the pulmonary veins","volume":"102","author":"Haissaguerre M","year":"2000","journal-title":"Circulation"},{"key":"e_1_2_8_8_2","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1161\/hc4601.098517","article-title":"Atrial electroanatomic remodelling after circumferential radiofrequency pulmonary vein ablation: Efficacy of an anatomic approach in a large cohort of patients with atrial fibrillation","volume":"104","author":"Pappone C","year":"2001","journal-title":"Circulation"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)03102-8"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104712"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2002.01067.x"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2009.01502.x"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1996.tb03269.x"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.12.054"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.00930.x"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000095796.45180.88"},{"key":"e_1_2_8_17_2","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1161\/CIRCULATIONAHA.104.491530","article-title":"Freedom from atrial tachyarrhythmias after catheter ablation of atrial fibrillation. A randomized comparison between 2 current ablation strategies","volume":"111","author":"Karch MR","year":"2005","journal-title":"Circulation"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000144459.37455.EE"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00569.x"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00673.x"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000130645.95357.97"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000146786.87037.26"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01189.x"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01145.x"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8167.2008.01379.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8167.2008.01379.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T23:39:50Z","timestamp":1696981190000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8167.2008.01379.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,21]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["10.1111\/j.1540-8167.2008.01379.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8167.2008.01379.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,21]]}}}