{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:44:28Z","timestamp":1791121468301,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,2,27]],"date-time":"2009-02-27T00:00:00Z","timestamp":1235692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:p> <jats:italic>Introduction:<\/jats:italic> In vitro studies and ambulatory ECG recordings from the MERLIN TIMI\u201036 clinical trial suggest that the novel antianginal agent ranolazine may have the potential to suppress atrial arrhythmias. However, there are no reports of effects of ranolazine on atrial electrophysiologic properties in large intact animals.<\/jats:p><jats:p> <jats:italic>Methods and Results:<\/jats:italic> In 12 closed\u2010chest anesthetized pigs, effects of intravenous ranolazine (\u223c9 \u03bcM plasma concentration) on multisite atrial effective refractory period (ERP), conduction time (CT), and duration and inducibility of atrial fibrillation (AF) initiated by intrapericardial acetylcholine were investigated. Ranolazine increased ERP by a median of 45 ms (interquartile range 29\u201350 ms; P &lt; 0.05, n = 6) in right and left atria compared to control at pacing cycle length (PCL) of 400 ms. However, ERP increased by only 28 (24\u201334) ms in right ventricle (P &lt; 0.01, n = 6). Ranolazine increased atrial CT from 89 (71\u2013109) ms to 98 (86\u2013121) ms (P = 0.04, n = 6) at PCL of 400 ms. Ranolazine decreased AF duration from 894 (811\u20131220) seconds to 621 (549\u2013761) seconds (P = 0.03, n = 6). AF was reinducible in 1 of 6 animals after termination with ranolazine compared with all 6 animals during control period (P = 0.07). Dominant frequency (DF) of AF was reduced by ranolazine in left atrium from 11.7 (10.7\u201320.5) Hz to 7.6 (2.9\u20138.8) Hz (P = 0.02, n = 6).<\/jats:p><jats:p> <jats:italic>Conclusions:<\/jats:italic> Ranolazine, at therapeutic doses, increased atrial ERP to greater extent than ventricular ERP and prolonged atrial CT in a frequency\u2010dependent manner in the porcine heart. AF duration and DF were also reduced by ranolazine. Potential role of ranolazine in AF management merits further investigation.<\/jats:p>","DOI":"10.1111\/j.1540-8167.2009.01437.x","type":"journal-article","created":{"date-parts":[[2009,2,27]],"date-time":"2009-02-27T15:41:27Z","timestamp":1235749287000},"page":"796-802","source":"Crossref","is-referenced-by-count":98,"title":["Ranolazine Exerts Potent Effects on Atrial Electrical Properties and Abbreviates Atrial Fibrillation Duration in the Intact Porcine Heart"],"prefix":"10.1111","volume":"20","author":[{"given":"KAPIL","family":"KUMAR","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BRUCE D.","family":"NEARING","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARCELO","family":"CARVAS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BRUNO C.G.","family":"NASCIMENTO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIANA","family":"ACAR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LUIZ","family":"BELARDINELLI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RICHARD L.","family":"VERRIER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,6,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.177292"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021328"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708789"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1161\/01.CIR.0000121736.16643.11","article-title":"Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow\u2010Up Investigation of Rhythm Management (AFFIRM) Study","volume":"109","author":"The AFFIRM Investigators","year":"2004","journal-title":"Circulation"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.16.1775"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.704890"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(03)00540-6"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2005.06.004"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2005.06.002"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2005.40689.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.01087.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01204.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00340-1"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1109\/10.942586"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000139333.83620.5D"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705879"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.724880"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.03.018"},{"key":"e_1_2_6_20_2","first-page":"175","article-title":"The effect of ranolazine on maintaining sinus rhythm in patients with resistant atrial fibrillation","volume":"8","author":"Murdock DK","year":"2008","journal-title":"Indian Pacing Electrophysiol J"},{"key":"e_1_2_6_21_2","unstructured":"BurashnikovA Di DiegoJM ZygmuntAC BelardinelliL AntzelevitchC:Atrial\u2010selective sodium channel block as a strategy for suppression of atrial fibrillation. 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