{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:30:32Z","timestamp":1772166632828,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,7,13]],"date-time":"2009-07-13T00:00:00Z","timestamp":1247443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:p> <jats:italic>Introduction:<\/jats:italic> Atrial electromechanical dysfunction might contribute to the development of atrial fibrillation (AF) in patients with sinus node disease (SND). The aim of this study was to investigate the prevalence and impact of atrial mechanical dyssynchrony on atrial function in SND patients with or without paroxysmal AF.<\/jats:p><jats:p> <jats:italic>Methods:<\/jats:italic> We performed echocardiographic examination with tissue Doppler imaging in 30 SND patients with (n = 11) or without (n = 19) paroxysmal AF who received dual\u2010chamber pacemakers. Tissue Doppler indexes included atrial contraction velocities (Va) and timing events (Ta) were measured at midleft atrial (LA) and right atrial (RA) wall. Intraatrial synchronicity was defined by the standard deviation and maximum time delay of Ta among 6 segments of LA (septal\/lateral\/inferior\/anterior\/posterior\/anterospetal). Interatrial synchronicity was defined by time delay between Ta from RA and LA free wall.<\/jats:p><jats:p> <jats:italic>Results:<\/jats:italic> There were no differences in age, P\u2010wave duration, left ventricular ejection fraction, LA volume, and ejection fraction between with or without AF. Patients with paroxysmal AF had lower mitral inflow A velocity (70 \u00b1 19 vs 91 \u00b1 17 cm\/s, P = 0.005), LA active empting fraction (24 \u00b1 14 vs 36 \u00b1 13%, P = 0.027), mean Va of LA (2.6 \u00b1 0.9 vs 3.4 \u00b1 0.9 cm\/s, P = 0.028), and greater interatrial synchronicity (33 \u00b1 25 vs 12 \u00b1 19 ms, P = 0.022) than those without AF. Furthermore, a lower mitral inflow A velocity (Odd ratio [OR]= 1.12, 95% Confidence interval [CI] 1.01\u20131.24, P = 0.025) and prolonged interatrial dyssynchrony (OR = 1.08, 95% CI 1.01\u20131.16, P = 0.020<jats:italic>)<\/jats:italic> were independent predictors for the presence of AF in SND patients.<\/jats:p><jats:p> <jats:italic>Conclusion:<\/jats:italic> SND patients with paroxysmal AF had reduced regional and global active LA mechanical contraction and increased interatrial dyssychrony as compared with those without AF. These findings suggest that abnormal atrial electromechanical properties are associated with AF in SND patients.<\/jats:p>","DOI":"10.1111\/j.1540-8167.2009.01547.x","type":"journal-article","created":{"date-parts":[[2009,7,13]],"date-time":"2009-07-13T10:04:32Z","timestamp":1247479472000},"page":"1237-1243","source":"Crossref","is-referenced-by-count":13,"title":["Interatrial Mechanical Dyssynchrony Worsened Atrial Mechanical Function in Sinus Node Disease With or Without Paroxysmal Atrial Fibrillation"],"prefix":"10.1111","volume":"20","author":[{"given":"MEI","family":"WANG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHU PAK","family":"LAU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XUE HUA","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHUNG\u2010WAH","family":"SIU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATHY L. 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