{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T01:53:09Z","timestamp":1762998789892},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,9,28]],"date-time":"2009-09-28T00:00:00Z","timestamp":1254096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p> <jats:bold>Neurally Mediated Syncope in Brugada Syndrome.<\/jats:bold>\n          <jats:bold>\n            <jats:italic>Introduction:<\/jats:italic>\n          <\/jats:bold> Patients with type 1 Brugada electrocardiogram (ECG) and an episode of syncope are diagnosed as symptomatic Brugada syndrome; however, all episodes of syncope may not be due to ventricular tachyarrhythmia.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Methods and Results:<\/jats:italic>\n          <\/jats:bold> Forty\u2010six patients with type 1 Brugada ECG (all males, 51 \u00b1 13 years, 29 spontaneous, 17 Ic\u2010drug induced), 20 healthy control subjects (all males, 35 \u00b1 11 years), and 15 patients with suspected neurally mediated syncope (NMS; 9 males, 54 \u00b1 22 years) underwent the head\u2010up tilt (HUT) test. During the HUT test, 12\u2010lead ECGs were recorded in all patients, and the heart rate variability was investigated in some patients. Sixteen (35%) of 46 patients with Brugada ECG, 2 (10%) of 20 control subjects, and 10 (67%) of 15 patients with suspected NMS showed positive responses to the HUT test. Although no significant differences were observed in HUT\u2010positive rate among Brugada patients with documented VT (7\/14; 50%), syncope (5\/19; 26%) and asymptomatic patients (4\/13; 31%), the HUT\u2010positive rate was significantly higher in patients with documented VT (50%) and those with VT or no symptoms (11\/27, 41%) compared to that in control subjects (10%) (P &lt; 0.05). Augmentation of ST\u2010segment amplitude (\u22650.05 mV) in leads V1\u2010V3 was observed in 11 (69%) of 16 HUT\u2010positive patients with Brugada ECG during vasovagal responses, and was associated with augmentation of parasympathetic tone following sympathetic withdrawal.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Conclusion:<\/jats:italic>\n          <\/jats:bold> Thirty\u2010five percent of patients with Brugada ECG showed vasovagal responses during the HUT test, suggesting that some Brugada patients have impaired balance of autonomic nervous system, which may relate to their syncopal episodes. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 21, pp. 186\u2010192, February 2010)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8167.2009.01599.x","type":"journal-article","created":{"date-parts":[[2009,9,28]],"date-time":"2009-09-28T13:50:42Z","timestamp":1254145842000},"page":"186-192","source":"Crossref","is-referenced-by-count":43,"title":["Neurally Mediated Syncope 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