{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T04:04:15Z","timestamp":1782619455921,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,10,5]],"date-time":"2009-10-05T00:00:00Z","timestamp":1254700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p> <jats:bold>LV Dysfunction in WPW Syndrome.\u2002<jats:italic>Introduction:<\/jats:italic><\/jats:bold> Echocardiographic studies have shown that some patients with Wolff\u2010Parkinson\u2010White (WPW) syndrome have myocardial dyskinesia in the segments precociously activated by an accessory pathway (AP). The aim of the present study was to determine the extent to which the AP contributes to global left ventricular (LV) dysfunction.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Methods:<\/jats:italic>\n          <\/jats:bold> Electrophysiological and echocardiographic data from 62 children with WPW (age at diagnosis = 5.9 \u00b1 4.2 years) were retrospectively analyzed.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Results:<\/jats:italic>\n          <\/jats:bold> The left ventricular ejection fraction (LVEF) of patients with septal APs (53 \u00b1 11%) was significantly lower than that of patients with right (62 \u00b1 5%) or left (61 \u00b1 4%) APs (P = 0.001). Compared to patients with normal septal motion (n = 56), patients with septal dyskinesia (n = 6) had a reduced LVEF (61 \u00b1 4% and 42 \u00b1 5%, respectively) and an increased LV end diastolic dimension (P &lt; 0.001 for both comparisons). Multivariate analysis identified septal dyskinesia as the only significant risk factor for reduced LVEF. All 6 patients with septal dyskinesia had right septal APs, and a preexcited QRS duration that was longer than that of patients with normal septal motion (140 \u00b1 18 ms and 113 \u00b1 32 ms, respectively; P = 0.045). After RFA there were improvements in both intraventricular dyssynchrony (septal\u2010to\u2010posterior wall motion delay, from 154 \u00b1 91 ms to 33 \u00b1 17 ms) and interventricular septal thinning (from 3.0 \u00b1 0.5 mm to 5.3 \u00b1 2.6 mm), and a significant increase in LVEF (from 42 \u00b1 5% to 67 \u00b1 8%; P = 0.001).<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Conclusion:<\/jats:italic>\n          <\/jats:bold> The dyskinetic segment activated by a right septal AP in WPW syndrome may lead to ventricular dilation and dysfunction. RFA produced mechanical resynchronization, reverse remodeling, and improvements in LV function. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 21, pp. 290\u2013295, March 2010)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8167.2009.01612.x","type":"journal-article","created":{"date-parts":[[2009,10,5]],"date-time":"2009-10-05T17:28:32Z","timestamp":1254763712000},"page":"290-295","source":"Crossref","is-referenced-by-count":70,"title":["Septal Dyskinesia and Global Left Ventricular Dysfunction in Pediatric Wolff\u2010Parkinson\u2010White Syndrome with Septal Accessory Pathway"],"prefix":"10.1111","volume":"21","author":[{"given":"BO SANG","family":"KWON","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EUN JUNG","family":"BAE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GI BEOM","family":"KIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHUNG IL","family":"NOH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUNG YUN","family":"CHOI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YONG SOO","family":"YUN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.54.4.567"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.53.6.943"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.54.2.174"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1016\/j.ijcard.2007.02.057","article-title":"Unique wall motion abnormalities on stress echocardiogram associated with Wolff\u2010Parkinson\u2010White pattern electrocardiogram: A case report","volume":"119","author":"Mulpuru SK","year":"2007","journal-title":"Int J Cardiol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951104006031"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.082115"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.01.003"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.571455"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.euje.2005.07.003","article-title":"Two\u2010dimensional acoustic pattern derived strain parameters closely correlate with one\u2010dimensional tissue Doppler derived strain measurements","volume":"7","author":"Modesto KM","year":"2006","journal-title":"Eur J Echocardiogr"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/0002-9149(76)90107-7","article-title":"Interventricular septal motion during preexcitation and normal conduction in Wolff\u2010Parkinson\u2010White syndrome: Echocardiographic and electrophysiologic correlation","volume":"37","author":"Ticzon AR","year":"1976","journal-title":"Am J Cardiol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1536\/ihj.18.329","article-title":"Phono\u2010, echo\u2010, and electro\u2010cardiographic correlation in the Wolff\u2010Parkinson\u2010White syndrome, with special reference to the split pattern of second heart sound","volume":"18","author":"Ito M","year":"1977","journal-title":"Jpn Heart J"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1378\/chest.71.4.463","article-title":"Relationship between the electrical (electrocardiographic) and mechanical (echocardiographic) events in Wolff\u2010Parkinson\u2010White syndrome","volume":"71","author":"Lebovitz JA","year":"1977","journal-title":"Chest"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.18.329"},{"key":"e_1_2_6_15_2","first-page":"599","article-title":"Echocardiographic study of movements of the interventricular septum in type B Wolff\u2010Parkinson\u2010White syndrome. 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