{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:27:06Z","timestamp":1767626826883},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,10,8]],"date-time":"2009-10-08T00:00:00Z","timestamp":1254960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p> <jats:bold>AF Ablation and PTMC.\u2002<jats:italic>Background:<\/jats:italic><\/jats:bold> The rhythm control of atrial fibrillation (AF) associated with mitral stenosis (MS) is often difficult using antiarrhythmic drugs (AADs), even after a percutaneous transvenous mitral commissurotomy (PTMC). Few studies have examined the efficacy and safety of simultaneously performing radiofrequency catheter ablation (RFCA) and a PTMC in patients with MS and AF.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Methods:<\/jats:italic>\n          <\/jats:bold> Twenty consecutive patients with drug\u2010resistant AF and rheumatic MS underwent RFCA combined with a PTMC (n = 10; persistent AF\u20108, long\u2010lasting [&gt;1 year] persistent AF\u20102; RFCA group) or transthoracic direct cardioversion (DC) following a PTMC (n = 10; persistent AF\u20107, long\u2010lasting persistent AF\u20103; DC group). In all patients, the mitral valve morphology was amenable to a PTMC, and more than 2 AADs had been ineffective in maintaining sinus rhythm (SR). In the RFCA group, a segmental pulmonary vein isolation (PVI) was performed in the initial 5 patients, and an extensive PVI was performed in the remaining 5.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Results:<\/jats:italic>\n          <\/jats:bold> During a mean follow\u2010up period of 4.0 \u00b1 2.7 years, 8 patients (80%) in the RFCA group were maintained in SR, as compared to 1 (10%) in the DC group (hazard ratio, 0.16; 95% confidence interval, 0.03 to 0.75; P = 0.008 by the log\u2010rank test). The prevalence of the concomitant use of class I and\/or class III AADs was comparable between the 2 groups (P = 0.70). No complications occurred during the procedure or follow\u2010up period in either group.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Conclusions:<\/jats:italic>\n          <\/jats:bold> The hybrid therapy using RFCA and a PTMC was safe and feasible, and significantly improved the AF free survival rate compared to DC following a PTMC. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 21, pp. 284\u2013289, March 2010)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8167.2009.01625.x","type":"journal-article","created":{"date-parts":[[2009,10,8]],"date-time":"2009-10-08T19:01:04Z","timestamp":1255028464000},"page":"284-289","source":"Crossref","is-referenced-by-count":10,"title":["Hybrid Therapy of Radiofrequency Catheter Ablation and Percutaneous Transvenous Mitral Commissurotomy in Patients With Atrial Fibrillation and Mitral Stenosis"],"prefix":"10.1111","volume":"21","author":[{"given":"TAKESHI","family":"MACHINO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIROSHI","family":"TADA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUKIO","family":"SEKIGUCHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YASUAKI","family":"TANAKA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHIGETO","family":"NAITO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIRO","family":"YAMASAKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAKANORI","family":"ARIMOTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIYAKO","family":"IGARASHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KENJI","family":"KUROKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOSHIHIRO","family":"SEO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHIGEYUKI","family":"WATANABE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIROSHI","family":"HOSHIZAKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHIGERU","family":"OSHIMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KOICHI","family":"TANIGUCHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAZUTAKA","family":"AONUMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,2,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)37390-8"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198512123132405"},{"key":"e_1_2_6_4_2","first-page":"568","article-title":"Atrial 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