{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:43:11Z","timestamp":1760121791106},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,11,17]],"date-time":"2009-11-17T00:00:00Z","timestamp":1258416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:p> <jats:bold>Quality of Life After Add\u2010on Arrhythmia Surgery<\/jats:bold>\u2002<jats:bold><jats:italic>Introduction:<\/jats:italic><\/jats:bold> This is a multicenter, prospective, randomized controlled trial to determine the effect of add\u2010on arrhythmia surgery on health\u2010related quality of life during 1\u2010year follow\u2010up of cardiac surgery patients with atrial fibrillation.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Methods:<\/jats:italic>\n          <\/jats:bold> 150 patients with documented atrial fibrillation were randomly assigned to undergo cardiac surgery with or without add\u2010on surgery. Patients completed quality of life questionnaires, comprising the RAND 36\u2010item Health Survey 1.0 (SF\u201036), Multidimensional Fatigue Inventory\u201020 (MFI\u201020) and EuroQoL (EQ\u20105D and VAS) at baseline and 3, 6, and 12 months following operation.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Results:<\/jats:italic>\n          <\/jats:bold> 132 patients completed the questionnaires at a minimum of one time\u2010point during follow\u2010up. At baseline patient characteristics, operative data and health\u2010related quality of life were comparable. At 12\u2010month follow\u2010up 62 patients were free of atrial fibrillation without significant differences between groups (P = 0.28). Conversion to SR occurred in 69.8% (37\/53) of patients with paroxysmal AF, in 28.2% (11\/39) of patients with permanent AF and in 44.4% (12\/27) of patients in persistent AF. Cardiac surgery in general resulted in an overall improvement of the RAND SF\u201036 and the MFI\u201020. However, the EQ\u20105D showed a significant deterioration in the subscale Pain\/Discomfort for both groups (P &lt; 0.001), with a significant worse outcome for the control group (P = 0.006).<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Conclusions:<\/jats:italic>\n          <\/jats:bold> Health\u2010related quality of life in patients with paroxysmal, permanent and persistent atrial fibrillation improves after cardiac surgery regardless of giving add\u2010on surgery or not, but this improvement is presumably more affected by treating the underlying heart disease than by restoring sinus rhythm. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 21, pp. 511\u2010520, May 2010)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8167.2009.01655.x","type":"journal-article","created":{"date-parts":[[2009,11,17]],"date-time":"2009-11-17T21:23:23Z","timestamp":1258493003000},"page":"511-520","source":"Crossref","is-referenced-by-count":21,"title":["A Prospective Randomized Multicenter Comparison on Health\u2010Related Quality of Life: The Value of Add\u2010On Arrhythmia Surgery in Patients with Paroxysmal, Permanent or Persistent Atrial Fibrillation Undergoing Valvular and\/or Coronary Bypass Surgery"],"prefix":"10.1111","volume":"21","author":[{"given":"H. 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