{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:24:42Z","timestamp":1792034682775,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,3,5]],"date-time":"2010-03-05T00:00:00Z","timestamp":1267747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p> <jats:bold>Drug\u2010Induced QTc Interval Assessment.<\/jats:bold>\u2002<jats:italic>Introduction:<\/jats:italic> There is debate on the optimal QT correction method to determine the degree of the drug\u2010induced QT interval prolongation in relation to heart rate (\u0394QTc).<\/jats:p><jats:p> <jats:italic>Methods:<\/jats:italic> Forty\u2010one patients (71 \u00b1 10 years) without significant heart disease who had baseline normal QT interval with narrow QRS complexes and had been implanted with dual\u2010chamber pacemakers were subsequently started on antiarrhythmic drug therapy. The QTc formulas of Bazett, Fridericia, Framingham, Hodges, and Nomogram were applied to assess the effect of heart rate (baseline, atrial pacing at 60 beats\/min, 80 beats\/min, and 100 beats\/min) on the derived \u0394QTc (QTc before and during antiarrhythmic therapy).<\/jats:p><jats:p> <jats:italic>Results:<\/jats:italic> Drug treatment reduced the heart rate (P &lt; 0.001) and increased the QT interval (P &lt; 0.001). The heart rate increase shortened the QT interval (P &lt; 0.001) and prolonged the QTc interval (P &lt; 0.001) by the use of all correction formulas before and during antiarrhythmic therapy. All formulas gave at 60 beats\/min similar \u0394QTc of 43 \u00b1 28 ms. At heart rates slower than 60 beats\/min, the Bazett and Framingham methods provided the most underestimated \u0394QTc values (14 \u00b1 32 ms and 18 \u00b1 34 ms, respectively). At heart rates faster than 60 beats\/min, the Bazett and Fridericia methods yielded the most overestimated \u0394QTc values, whereas the other 3 formulas gave similar \u0394QTc increases of 32 \u00b1 28 ms.<\/jats:p><jats:p> <jats:italic>Conclusions:<\/jats:italic> Bazett's formula should be avoided to assess \u0394QTc at heart rates distant from 60 beats\/min. The Hodges formula followed by the Nomogram method seem most appropriate in assessing \u0394QTc. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 21, pp. 905\u2010913, August 2010)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8167.2010.01738.x","type":"journal-article","created":{"date-parts":[[2010,3,5]],"date-time":"2010-03-05T20:10:50Z","timestamp":1267819850000},"page":"905-913","source":"Crossref","is-referenced-by-count":54,"title":["Preferred QT Correction Formula for the Assessment of Drug\u2010Induced QT Interval Prolongation"],"prefix":"10.1111","volume":"21","author":[{"given":"JOHN","family":"CHILADAKIS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANDREAS","family":"KALOGEROPOULOS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PANAGIOTIS","family":"ARVANITIS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NIKOLAOS","family":"KOUTSOGIANNIS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FANI","family":"ZAGLI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DIMITRIOS","family":"ALEXOPOULOS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,3]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(90)90180-W"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.08.067"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.12.014"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00119-X"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90035-B"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(96)90525-6"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-0736(88)90096-9"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1999.tb00635.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-0736(90)90085-G"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.87.3.220"},{"key":"e_1_2_6_12_2","first-page":"353","article-title":"An analysis of time relations of electrocardiograms","volume":"7","author":"Bazett JC","year":"1920","journal-title":"Heart"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","article-title":"Chamber Quantification Writing Group; American Society of Echocardiography's Guidelines and Standards Committee; European Association of Echocardiography","volume":"18","author":"Lang RM","year":"2005","journal-title":"J Am Soc Echocardiogr"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/22.1.67"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90562-D"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1920.tb18266.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2004.08.030"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90654-8"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2001.00411.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1991.tb04109.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.77.2.128"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.86.2.199"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8167.2010.01738.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8167.2010.01738.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T11:02:28Z","timestamp":1698922948000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8167.2010.01738.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["10.1111\/j.1540-8167.2010.01738.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8167.2010.01738.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}