{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:56:42Z","timestamp":1791982602329,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,12,6]],"date-time":"2010-12-06T00:00:00Z","timestamp":1291593600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p> <jats:bold>High\u2010Rate Pacing Prevents Drug\u2010Induced Arrhythmias.<\/jats:bold>\u2002<jats:italic>Introduction:<\/jats:italic> High\u2010rate pacing may have an inhibitory effect on the initiation of Torsade de Pointes arrhythmias (TdP). However, permanent pacing is only indicated in high\u2010risk patients. We performed a proof of concept study into automatic overdrive pacing for prevention of drug\u2010induced TdP, using short\u2010term variability of repolarization (STV) as a feedback parameter of arrhythmic risk.<\/jats:p><jats:p> <jats:italic>Methods and Results:<\/jats:italic> The minimal signal sampling frequency required for measuring STV was determined through computer simulation. Arrhythmogenic response to dofetilide (25 \u03bcg\/kg\/5minutes) was tested at two different paced heart rates (60\u201365 bpm vs 100\u2013110 bpm) in 7 dogs with chronic atrioventricular block, while recording right and left ventricular (LV) monophasic action potential (MAP) and LV electrogram (EGM). Simulations showed a sampling frequency of 500 Hz is sufficient to capture relevant STV values. High\u2010rate pacing prevented dofetilide\u2010induced TdP seen at the low rate (low: 6\/7 vs high: 1\/7). At the low rate, STV from LV MAP duration increased before occurrence of spontaneous, ectopic activity and TdP (1.7 \u00b1 0.6\u20133.0 \u00b1 1.8 ms, P &lt; 0.05), but at the high\u2010rate STV did not change significantly (0.9 \u00b1 0.2\u20131.5 \u00b1 1.4 ms, NS). Regression analysis showed a close relation between STV calculated from LV MAP and from LV EGM (R<jats:sup>2<\/jats:sup>= 0.71).<\/jats:p><jats:p> <jats:italic>Conclusions:<\/jats:italic> High\u2010rate pacing increases repolarization reserve in dogs with chronic atrioventricular block, preventing dofetilide\u2010induced TdP. Changes in repolarization reserve are reflected in values of STV. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 21, pp. 1384\u20101391, December 2010)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8167.2010.01824.x","type":"journal-article","created":{"date-parts":[[2010,6,17]],"date-time":"2010-06-17T21:28:02Z","timestamp":1276810082000},"page":"1384-1391","source":"Crossref","is-referenced-by-count":25,"title":["High\u2010Rate Pacing Reduces Variability of Repolarization and Prevents Repolarization\u2010Dependent Arrhythmias in Dogs With Chronic AV Block"],"prefix":"10.1111","volume":"21","author":[{"given":"PETER","family":"OOSTERHOFF","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MORTEN B.","family":"THOMSEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOEP 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