{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:58:20Z","timestamp":1769126300207,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,2,18]],"date-time":"2011-02-18T00:00:00Z","timestamp":1297987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p> <jats:bold>Resynchronizing Pacemaker\u2010Dependent Patients. <jats:italic>Introduction:<\/jats:italic><\/jats:bold> Right ventricular (RV) pacing engenders left ventricular (LV) dyssynchrony and may diminish LV systolic function, promote adverse cardiac remodeling, and foster heart failure (HF). This process may be reversible in some pacemaker\u2010dependent patients upgraded to cardiac resynchronization therapy (CRT). We examined the clinical characteristics of pacemaker\u2010dependent patients who exhibit hyperresponse (i.e., normalization of LV function) with CRT upgrade.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Methods and Results<\/jats:italic>\n          <\/jats:bold>: We identified 51 chronically RV\u2010paced patients with no coronary artery disease, LV ejection fraction (EF) \u2264 35%, and severe HF symptoms who were upgraded to CRT\u2010defibrillators (CRT\u2010D). Echocardiograms were performed before and \u22656 months after CRT. Patients with follow\u2010up LVEF \u2265 50% were deemed hyperresponders. Clinical outcomes of death, cardiac transplant, mechanical circulatory support, and HF hospitalizations were assessed. Fifteen patients were CRT hyperresponders; all demonstrated \u226515% relative LV end\u2010systolic volume decrease. Hyperresponders had smaller baseline LV dimensions and shorter known cardiomyopathy duration than nonhyperresponders (P &lt; 0.01). The best predictors of hyperresponse using receiver operating characteristic analysis were LV end\u2010systolic dimension &lt;48 mm (area under the curve [AUC] 0.92, P &lt; 0.001), LV end\u2010diastolic dimension &lt;58 mm (AUC 0.86, P &lt; 0.001), and cardiomyopathy duration &lt;24 months (AUC 0.82, P &lt; 0.001). No hyperresponders died, received a cardiac transplant, or required mechanical circulatory support during 42 \u00b1 22 months follow\u2010up, whereas 5 nonhyperresponders died, 2 underwent transplant, and 1 required an assist device (log rank P = 0.049).<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Conclusion<\/jats:italic>\n          <\/jats:bold>: Among chronically RV paced patients who are upgraded to CRT\u2010D, smaller baseline LV dimensions and shorter known cardiomyopathy duration predict hyperresponse. Hyperresponders have excellent long\u2010term survival. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 22, pp. 905\u2010911, August 2011)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8167.2011.02018.x","type":"journal-article","created":{"date-parts":[[2011,2,18]],"date-time":"2011-02-18T21:50:14Z","timestamp":1298065814000},"page":"905-911","source":"Crossref","is-referenced-by-count":35,"title":["Predicting Hyperresponse Among Pacemaker\u2010Dependent Nonischemic Cardiomyopathy Patients Upgraded to Cardiac Resynchronization"],"prefix":"10.1111","volume":"22","author":[{"given":"EVAN","family":"ADELSTEIN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID","family":"SCHWARTZMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN","family":"GORCSAN 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