{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:16:31Z","timestamp":1761765391656},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,3,3]],"date-time":"2011-03-03T00:00:00Z","timestamp":1299110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p> <jats:bold>Baseline BNP Predicts Ablation Outcome in Male AF Patients. <jats:italic>Background:<\/jats:italic> Close association between atrial fibrillation (AF) and brain natriuretic peptide (BNP) has been demonstrated by several studies. Important gender differences exist in AF patients including a higher plasma BNP level in women. Therefore, it is imperative to evaluate the relationship between AF and BNP separately in men and women.<\/jats:bold> <\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Objective:<\/jats:italic> This study examined possible gender\u2010specific role of BNP in predicting procedure outcome in AF patients undergoing catheter ablation.<\/jats:bold> <\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Method:<\/jats:italic> The study population included 568 consecutive patients (age 62 \u00b1 10, male 73%, paroxysmal 25%, persistent 38%, and long\u2010standing persistent AF 37%) undergoing AF ablation, who had structurally normal heart and left ventricular ejection fraction \u226545%. Baseline BNP was measured in all. Patients were grouped into \u201cnormal\u201d and \u201chigh\u201d BNP based on gender\u2010specific cut\u2010off values (&lt;50 and \u226550 pg\/mL in males, &lt;100 and \u2265 100 pg\/mL in females).<\/jats:bold> <\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Result:<\/jats:italic> Baseline BNP was significantly higher among women than men (126 \u00b1 112 versus 87 \u00b1 99, P = 0.009). At 12 \u00b1 6 month follow\u2010up, 304 of 414 (73%) males and 98 of 154 (64%) females were AF\/atrial tachycardia\u2010free off antiarrhythmic drugs (log\u2010rank P = 0.018). In multivariable analysis, BNP remained an independent predictor of AF recurrence (BNP \u2265 50: hazard ratio [HR] 2.54, P = 0.006) in males. No such association was observed among females (BNP \u2265 100: HR 0.79, 95% CI 0.43\u20131.42; P = 0.426).<\/jats:bold> <\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Conclusion:<\/jats:italic> Baseline BNP was found to be an independent predictor of AF recurrence in male patients undergoing ablation. This correlation between BNP and AF recurrence was not observed in females. Thus, BNP plays a gender\u2010specific prognostic role in AF<\/jats:bold>. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 22, pp. 858\u2010865, August 2011)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8167.2011.02036.x","type":"journal-article","created":{"date-parts":[[2011,3,6]],"date-time":"2011-03-06T00:45:56Z","timestamp":1299372356000},"page":"858-865","source":"Crossref","is-referenced-by-count":17,"title":["Baseline B\u2010Type Natriuretic Peptide: A Gender\u2010Specific Predictor of Procedure\u2010Outcome in Atrial Fibrillation Patients Undergoing Catheter Ablation"],"prefix":"10.1111","volume":"22","author":[{"given":"SANGHAMITRA","family":"MOHANTY","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PRASANT","family":"MOHANTY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LUIGI","family":"DI BIASE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BAI","family":"RONG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID","family":"BURKHARDT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOSEPH G.","family":"GALLINGHOUSE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RODNEY","family":"HORTON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAVIER E.","family":"SANCHEZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHANE","family":"BAILEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JASON","family":"ZAGRODZKY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREA","family":"NATALE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,3]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.12.071"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-007-9002-9"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.10.047"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02059-4"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.19.2365"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.07.007"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00789-7"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-009-0744-3"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2010.04.019"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2007.10.004"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.037"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.921320"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.928903"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.10.025"},{"key":"e_1_2_7_16_2","article-title":"Outcome of invasive electrophysiological procedures and gender: are males and females the same?","author":"Santangeli P","journal-title":"J Cardiovasc Electrophysiol"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2005.10.018"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20040349"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02464-5"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1515\/bchm3.1992.373.1.213"},{"key":"e_1_2_7_21_2","article-title":"Association of sex hormone status with circulating natriuretic peptides","volume":"122","author":"Lam Carolyn S","year":"2010","journal-title":"Circulation"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.10.040"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs1010447"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02999.x"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(93)90245-X"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.6.1307"},{"key":"e_1_2_7_27_2","first-page":"241","article-title":"Predicting successful pulmonary vein isolation in patients with atrial fibrillation by brain natriuretic peptide plasma levels","volume":"9","author":"Shin D","year":"2009","journal-title":"Indian Pacing Electrophysiol J"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8167.2011.02036.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8167.2011.02036.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T02:57:22Z","timestamp":1697338642000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8167.2011.02036.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,3]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["10.1111\/j.1540-8167.2011.02036.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8167.2011.02036.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,3]]}}}