{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T03:07:20Z","timestamp":1769915240800,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,7,21]],"date-time":"2011-07-21T00:00:00Z","timestamp":1311206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2012,1]]},"abstract":"Long\u2010Term Observation with ILR<\/jats:bold>. Introduction<\/jats:italic><\/jats:bold>:<\/jats:italic> In the literature, the average diagnostic yield of the implantable loop recorder (ILR) is reported to be 35% over an observation period generally less than 18 months. The aim of this study was to evaluate the diagnostic value of ILR during very prolonged observation.<\/jats:p>\n Methods and Results:<\/jats:italic>\n <\/jats:bold> Consecutive patients who had received one or more (in the case of battery exhaustion before diagnosis) ILR (Reveal\/plus\/DX, Medtronic Inc.) from 2001 to 2010 were included. The diagnostic ECG was classified according to the ISSUE classification. We analyzed 157 patients (87 males, 69 \u00b1 14 years): 70 of these were followed up for \u226518 months. The estimated cumulative diagnostic rates were 30%, 43%, 52%, and 80% at 1, 2, 3, and 4 years, respectively; 26% of diagnoses were made after 18 months. The diagnostic yield was independent of structural heart disease, bundle branch block, number of syncopes, age, and gender; the median time to diagnosis of ISSUE type 1 patients was shorter than that of the others (4 [2;10] vs. 16 [6;23] months; P = 0.003). During the observation period, 3 patients (1.9%) died and none suffered arrhythmic death.<\/jats:p>\n Conclusions:<\/jats:italic>\n <\/jats:bold> Prolonging observation up to 4 years increased the diagnostic value of ILR in syncopal patients and was safe. A quarter of patients diagnosed needed more than 18 months of follow\u2010up. As consequence, when a strategy of prolonging monitoring is chosen, monitoring should be maintained even for several years until diagnosis is established. (J Cardiovasc Electrophysiol, Vol. 23, pp. 67\u201071, January 2012)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8167.2011.02133.x","type":"journal-article","created":{"date-parts":[[2011,7,21]],"date-time":"2011-07-21T19:34:57Z","timestamp":1311276897000},"page":"67-71","source":"Crossref","is-referenced-by-count":66,"title":["Additional Diagnostic Value of Very Prolonged Observation by Implantable Loop Recorder in Patients with Unexplained Syncope"],"prefix":"10.1111","volume":"23","author":[{"given":"TOSHIYUKI","family":"FURUKAWA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROBERTO","family":"MAGGI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CRISTINA","family":"BERTOLONE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DANIELE","family":"FONTANA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHELE","family":"BRIGNOLE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp298"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eup097"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi842"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.3.406"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.043"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.116616"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi602"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02621-9"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.104.1.46"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000018125.31973.87"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4201.097837"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euq418"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3601.095708"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eupc.2004.11.001"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8167.2011.02133.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8167.2011.02133.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T14:20:58Z","timestamp":1698675658000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8167.2011.02133.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,21]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1111\/j.1540-8167.2011.02133.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8167.2011.02133.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,21]]}}}