{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:30:24Z","timestamp":1782257424921,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,9,2]],"date-time":"2011-09-02T00:00:00Z","timestamp":1314921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p><jats:bold>Predictors of AF Recurrence After Cryoballoon PVI.\u2002<jats:italic>Introduction:<\/jats:italic><\/jats:bold> In patients with atrial fibrillation (AF) undergoing pulmonary vein isolation, cryoballoon technique (cryoPVI) has been adopted in many centers. This study aimed to evaluate predictors of AF recurrence including impact of sleep\u2010disordered breathing (SDB).<\/jats:p><jats:p><jats:bold>\n            <jats:italic>Methods and Results:<\/jats:italic>\n          <\/jats:bold> In 82 patients consecutively assigned to cryoPVI cardiorespiratory screening for SDB, assessment of medical history, ECG, echocardiography, standard laboratory measurement, and blood gas analysis were performed prior to intervention. After a 3\u2010month blanking period, a 7\u2010day Holter ECG was performed at 3, 6 and then every 6 months to determine AF recurrence. Seventy\u2010five patients (69 paroxysmal AF, 6 persistent AF, 22 female, age 60 \u00b1 9 years) completed at least 6\u2010month follow\u2010up. Median follow\u2010up of 12 months (interquartile range 6\u201318 months) confirmed maintenance of sinus rhythm in 69.4% of these patients. Stepwise forward regression model revealed moderate to severe SDB (cut\u2010off apnea\u2010hypopnea\u2010index (AHI) \u2265 15 per hour; Hazard Ratio (HR) 2.95, P = 0.04), early recurrence of AF (HR 8.74, P &lt; 0.001), persistent AF (HR 7.16, P &lt; 0.001), preprocedural class III\u2010antiarrhythmic drug treatment (HR 3.63, P = 0.02), but not SDB <jats:italic>per se<\/jats:italic> (AHI \u2265 5 per hour) as independent predictors for AF recurrence.<\/jats:p><jats:p><jats:bold>\n            <jats:italic>Conclusion:<\/jats:italic>\n          <\/jats:bold> Moderate to severe SDB is a treatable condition that independently predicts AF recurrence in patients undergoing cryoPVI. Screening for SDB and adequate treatment may improve long\u2010term success of cryoPVI. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 23, pp. 18\u201025, January 2012)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8167.2011.02148.x","type":"journal-article","created":{"date-parts":[[2011,9,2]],"date-time":"2011-09-02T19:11:26Z","timestamp":1314990686000},"page":"18-25","source":"Crossref","is-referenced-by-count":54,"title":["Predictors of Recurrence in Patients Undergoing Cryoballoon Ablation for Treatment of Atrial Fibrillation: The Independent Role of Sleep\u2010Disordered Breathing"],"prefix":"10.1111","volume":"23","author":[{"given":"THOMAS","family":"BITTER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GEORG","family":"N\u00d6LKER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00dcRGEN","family":"VOGT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTIAN","family":"PRINZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DIETER","family":"HORSTKOTTE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OLAF","family":"OLDENBURG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,2]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71141-7"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201003-0406OC"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909233411304"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn214"},{"key":"e_1_2_9_6_2","first-page":"164","article-title":"Sleep\u2010disordered breathing in patients with atrial fibrillation and normal systolic left ventricular function","volume":"106","author":"Bitter T","year":"2009","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000136587.68725.8E"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl176"},{"key":"e_1_2_9_9_2","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.hrthm.2007.04.005","article-title":"HRS\/EHRS\/ECAS expert Consensus Statement on catheter and surgical ablation of atrial fibrillation: Recommendations for personnel, policy, procedures and follow\u2010up. 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