{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T15:25:45Z","timestamp":1771082745034,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T00:00:00Z","timestamp":1319760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>Reduced Vagal Control in Heart Failure.<\/jats:p><jats:p><jats:italic>Objective:<\/jats:italic> We tested the hypothesis that heart failure (HF) results in right atrial ganglionated plexus (RAGP) denervation that contributes to sinoatrial node dysfunction.<\/jats:p><jats:p><jats:italic>Background:<\/jats:italic> HF is associated with sinoatrial node dysfunction. However, the detailed mechanisms remain unclear.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic> We recorded nerve activity (NA) from the RAGP, right stellate ganglion (SG), and right vagal nerve in 7 ambulatory dogs at baseline and after pacing\u2010induced HF. We also determined the effects of RAGP stimulation in isolated normal and HF canine RA.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> NAs in both the SG and vagal were significantly higher in HF than at baseline. The relationship between 1\u2010minute integrated NAs of vagal and RAGP showed either a positive linear correlation (Group 1, n = 4) or an L\u2010shaped correlation (Group 2, n = 3). In all dogs, a reduced heart rate was observed when vagal\u2010NA was associated with simultaneously increased RAGP\u2010NA. On the other hand, when vagal\u2010NA was not associated with increased RAGP\u2010NA, the heart rate was not reduced. The induction of HF significantly decreased RAGP\u2010NA in all dogs (P &lt; 0.05). Stimulating the superior RAGP in isolated RA significantly reduced the sinus rate in normal but not the HF hearts. Immunohistochemical staining revealed lower densities of tyrosine hydroxylase\u2010 and choline acetyltransferase\u2010positive nerve tissues in HF RAGP than normal (P &lt; 0.001 and P = 0.001, respectively).<\/jats:p><jats:p><jats:italic>Conclusions:<\/jats:italic> The RAGP\u2010NA is essential for the vagal nerve to counterbalance the SG in sinus rate control. In HF, RAGP denervation and decreased RAGP\u2010NA contribute to the sinus node dysfunction.<\/jats:p>","DOI":"10.1111\/j.1540-8167.2011.02204.x","type":"journal-article","created":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T12:06:42Z","timestamp":1319803602000},"page":"404-412","source":"Crossref","is-referenced-by-count":21,"title":["Heart Failure Decreases Nerve Activity in the Right Atrial Ganglionated Plexus"],"prefix":"10.1111","volume":"23","author":[{"given":"TETSUJI","family":"SHINOHARA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARK J.","family":"SHEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SEONGWOOK","family":"HAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MITSUNORI","family":"MARUYAMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HYUNG\u2010WOOK","family":"PARK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHAEL C.","family":"FISHBEIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHANGYU","family":"SHEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PENG\u2010SHENG","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHIEN\u2010FONG","family":"LIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,28]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2002.00735.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.066"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2007.041178"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp194"},{"key":"e_1_2_7_6_2","first-page":"2615","volume":"121","author":"Choi EK","year":"2010","journal-title":"Intrinsic cardiac nerve activity and paroxysmal atrial tachyarrhythmia in ambulatory dogs. 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