{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:35:34Z","timestamp":1791106534646,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,11,14]],"date-time":"2011-11-14T00:00:00Z","timestamp":1321228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p><jats:bold>Risk of Mortality for Ventricular Arrhythmia<\/jats:bold>. <jats:italic>Background:<\/jats:italic> There are limited data regarding the incidence and prognostic significance of ventricular arrhythmias (VA) in ambulatory continuous flow left ventricular assist device (LVAD) patients.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic> Sixty\u2010one consecutive patients from November 1, 2006 through December 31, 2010 with an LVAD and implantable cardioverter defibrillator that survived to discharge from the LVAD implantation admission were studied. Follow\u2010up began from date of discharge with both devices <jats:italic>in situ<\/jats:italic> and ended with death, transplant, on June 1, 2011. Pre\u2010LVAD VA history was related to the primary endpoints of post\u2010LVAD VA, mortality, and the combined endpoint of post\u2010LVAD VA\/mortality.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> During a mean follow\u2010up of 622 days 19 patients (31%) experienced VA (14 episodes of VT, 5 episodes of VF). Pre\u2010LVAD VA was predictive of post\u2010LVAD VA (hazard ratio [HR] 2.91, P = 0.026) and the combined post\u2010LVAD VA\/mortality endpoint (HR 2.70, P = 0.021) but only displayed a nonsignificant association with mortality (HR 2.30, P = 0.11). In multivariate analysis, pre\u2010LVAD VA remained a significant predictor of post\u2010LVAD VA (HR 2.84, P = 0.03) and the combined post\u2010LVAD VA\/mortality endpoint (HR 2.65, P = 0.025). Post\u2010LVAD VA was the strongest univariate predictor of mortality (HR 13.92, P &lt; 0.001) and remained so after multivariate adjustment (HR 9.69, P = 0.001). Post\u2010LVAD VA occurred at a mean of 1 year from mortality events with 45% within 1 month.<\/jats:p><jats:p><jats:italic>Conclusions:<\/jats:italic> Pre\u2010LVAD VA is a significant predictor of post\u2010LVAD VA but not of mortality. VA in the continuous flow LVAD population carries a significant risk of mortality often within the first month. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 23, pp. 515\u2010520, May 2012)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8167.2011.02223.x","type":"journal-article","created":{"date-parts":[[2011,11,15]],"date-time":"2011-11-15T06:29:32Z","timestamp":1321338572000},"page":"515-520","source":"Crossref","is-referenced-by-count":94,"title":["Risk of Mortality for Ventricular Arrhythmia in Ambulatory LVAD Patients"],"prefix":"10.1111","volume":"23","author":[{"given":"ANDREW","family":"BRENYO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MOHAN","family":"RAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SUSHMA","family":"KONERU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WILLIAM","family":"HALLINAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SAMIT","family":"SHAH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. T.","family":"MASSEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LEWAY","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BRONISLAVA","family":"POLONSKY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SCOTT","family":"MCNITT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAVID T.","family":"HUANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ILAN","family":"GOLDENBERG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MEHMET","family":"AKTAS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,14]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.03.011"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.11.051"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.12.022"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.09.044"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.02.001"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071098"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.11.038"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2008.01173.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.035"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2009.12.003"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8167.2011.02223.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8167.2011.02223.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T10:19:48Z","timestamp":1698661188000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8167.2011.02223.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,14]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1111\/j.1540-8167.2011.02223.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8167.2011.02223.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,14]]}}}