{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:37:58Z","timestamp":1790861878453,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,12,2]],"date-time":"2011-12-02T00:00:00Z","timestamp":1322784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p><jats:bold>Methadone and QT Prolongation<\/jats:bold>.\u2002<jats:italic>Background:<\/jats:italic> Methadone is associated with QTc prolongation and sudden death in susceptible patients. We sought to investigate whether there is a gender\u2010based difference in susceptibility to methadone\u2010associated QTc prolongation in heroin\u2010dependent patients receiving a low\u2010dose treatment regimen.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic> A cross\u2010sectional assessment of dose and gender effects was performed in 283 patients (229 males, 54 females) who received a 12\u2010lead ECG for QTc measurement 59 days (interquartile range: 36\u2013288 days) after methadone treatment. To determine the effects of methadone over time, a subset of 150 participants (126 men, 24 women) who underwent a 12\u2010lead ECG before and 37 days (interquartile range: 32\u201344 days) after methadone treatment were selected.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> In the cross\u2010sectional study, a significant dose\u2010dependent interaction between methadone and QTc (r = 0.201, P = 0.0007) was observed in individuals receiving a median methadone dose of 40 mg\/day (interquartile range: 30\u201360 mg\/day). The methadone\u2010QTc correlation was significant in males (r = 0.210, P = 0.0014) but not in females (r = 0.164, P = 0.2363). The longitudinal assessment of methadone's effects over a 6\u2010month period showed that 60.7% of individuals experienced an increase in QTc compared to baseline data. The adjusted QTc significantly increased from 418.5 to 426.9 milliseconds in males (P &lt; 0.0001), compared to an insignificant change in females (437.7 milliseconds vs 441.1 milliseconds, P = 0.468).<\/jats:p><jats:p><jats:italic>Conclusions:<\/jats:italic> Low\u2010dose methadone therapy shows dose\u2010dependent QTc prolongation and is associated with significant QTc lengthening within 6 months of treatment initiation. Men are more susceptible than women to low\u2010dose methadone\u2010associated QTc prolongation. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 23, pp. 527\u2010533, May 2012)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8167.2011.02231.x","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T17:38:42Z","timestamp":1322933922000},"page":"527-533","source":"Crossref","is-referenced-by-count":23,"title":["Gender\u2010Specific Differences in Susceptibility to Low\u2010Dose Methadone\u2010Associated QTc Prolongation in Patients with Heroin 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