{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:57:08Z","timestamp":1760029028019},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T00:00:00Z","timestamp":1333497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p><jats:bold>Course and Prognostic Implication of QT After CABG<\/jats:bold>.\u2002<jats:italic>Introduction:<\/jats:italic> The aim of the present study was to determine the prognostic implication of preoperative QT interval in relation to overall death and sudden cardiac death after coronary bypass surgery and to investigate the course of QT interval after surgery.<\/jats:p><jats:p><jats:italic>Methods and Results:<\/jats:italic> Of 812 consecutive patients undergoing isolated off\u2010pump coronary surgery, 656 were retrospectively analyzed after excluding the 48 patients who were taking QT prolonging drugs and the 108 patients who had any of the following electrocardiographic findings: atrial fibrillation, pacemaker, QRS of &gt;120 milliseconds, bundle branch block. QT intervals were corrected for heart rate (QTc) using Bazett's formula. Prolonged QTc was defined as QTc of \u2265450 milliseconds in men (n = 144) and \u2265470 milliseconds in women (n = 36). The 5\u2010year cumulative rate of sudden cardiac death in patients with prolonged QTc was 25% against 4% for those with normal QTc (P = 0.01). The risk\u2010adjusted hazard ratio (95% confidence interval) for the association between preoperative QTc and overall death was 1.47 (1.21\u20131.74) per 1\u2010SD increase in QTc; and 2.38 (1.50\u20133.45) for prolonged versus normal QT. For sudden cardiac death, the respective ratios were 1.63 (1.32\u20132.25) per 1\u2010SD increase in QTc; and 3.32 (2.14\u20134.23). QTc interval did not change during the first year after surgery, but increased significantly during the subsequent years. Patients with prolonged QTc before surgery had consistently longer QTc even after revascularization than those with normal QTc.<\/jats:p><jats:p><jats:italic>Conclusion:<\/jats:italic> Preoperative QT interval was an independent predictor of overall death and sudden cardiac death after isolated coronary bypass surgery. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 23, pp. 645\u2013649, June 2012)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8167.2011.02244.x","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T18:35:17Z","timestamp":1333564517000},"page":"645-649","source":"Crossref","is-referenced-by-count":8,"title":["Time Course and Prognostic Implications of QT Interval in Patients with Coronary Artery Disease Undergoing Coronary Bypass Surgery"],"prefix":"10.1111","volume":"23","author":[{"given":"TAKESHI","family":"KINOSHITA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TOHRU","family":"ASAI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TOMOAKI","family":"SUZUKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KEIJI","family":"MATSUBAYASHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MINORU","family":"HORIE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,4]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"KannelWB GagnonDR CupplesLA:Epidemiology of sudden coronary death: Population at risk.Can J Cardiol1990;6:439\u2013444."},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","unstructured":"MyerburgRJ InterianAJr MitraniRM KesslerKM CastellanosA:Frequency of sudden cardiac death and profiles of risk.Am J Cardiol1997;80:10F\u201319F.","DOI":"10.1016\/S0002-9149(97)00477-3"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","unstructured":"ChughSS ReinierK SinghT Uy\u2010Evanado\u2002 SocoteanuC PetersD MarianiR GunsonK JuiJ:Determinants of prolonged QT interval and their contribution to sudden death risk in coronary artery disease. The Oregon sudden unexpected death study.Circulation2009;119:663\u2013670.","DOI":"10.1161\/CIRCULATIONAHA.108.797035"},{"key":"e_1_2_6_5_2","unstructured":"VrtovecB YazdanbakhshA PintarT CollardSD GregoricID RadovancevicB:QTc interval prolongation predicts postoperative mortality in heart failure patients undergoing surgical revascularization.Tex Heart Inst J2006;33:3\u20138."},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","unstructured":"ForoughiM YousefiZK TehraniMM ForoutagheAN GhanavatiA HassantashSA:Prolonged QT interval and coronary artery bypass mortality due to heart failure.Asian Cardiovasc Thorac Ann2009;17:604\u2013607.","DOI":"10.1177\/0218492309349068"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","unstructured":"KinoshitaT AsaiT NishimuraO SuzukiT KambaraA MatsubayashiK:Off\u2010pump bilateral versus single skeletonized internal thoracic artery grafting in patients with diabetes.Ann Thorac Surg2010;90:1173\u20131179.","DOI":"10.1016\/j.athoracsur.2010.05.048"},{"key":"e_1_2_6_8_2","unstructured":"BazettHC:An analysis of time relations of the electrocardiogram.Heart1920;7:353\u2013370."},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","unstructured":"SundstromJ LindL ArnlovJ ZetheliusB AndrenB LithellHO:Echocardiographic and electrocardiographic diagnoses of left ventricular hypertrophy predict mortality independently of each other in a population of elderly men.Circulation2001;103:2346\u20132351.","DOI":"10.1161\/01.CIR.103.19.2346"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","unstructured":"CasalePN DevereuxRB AlonsoDR CampoE KligfieldP:Improved sex\u2010specific criteria of left ventricular hypertrophy for clinical and computer interpretation of electrocardiograms: validation with autopsy findings.Circulation1987;75:565\u2013572.","DOI":"10.1161\/01.CIR.75.3.565"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","unstructured":"MatsuoS ImaiE HorioM YasudaY TomitaK NittaK YamagataK TominoY YakoyamaH HishidaA:Revised equations for estimated GFR from serum creatinine in Japan.Am J Kidney Dis2009;53:982\u2013992.","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","unstructured":"YavuzB DumanU AbaliG DoganOF YaziciogluA SahinerL AytemirK TokgozogluL DemircinM NazliN KabakciG OtoA:Coronary artery bypass grafting is associated with a significant worsening of QT dynamicity and heart rate variability.Cardiology2006;106:51\u201355.","DOI":"10.1159\/000092599"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","unstructured":"CagliK OzbakirC ErgunK BakuyV CirciR CirciP:Electrocardiographic changes after coronary artery surgery.Asian Cardiovasc Thorac Ann2006;14:294\u2013299.","DOI":"10.1177\/021849230601400406"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","unstructured":"KosarF NisanogluV AksoyY ColakC ErdilN BattalogluB:Effects of coronary revascularization and concomitant aneurysmectomy on QT interval duration and dispersion.J Electrocardiol2006;39:194\u2013198.","DOI":"10.1016\/j.jelectrocard.2005.08.010"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8167.2011.02244.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8167.2011.02244.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T22:21:37Z","timestamp":1697322097000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8167.2011.02244.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,4]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1540-8167.2011.02244.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8167.2011.02244.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,4]]}}}