{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:58:18Z","timestamp":1762505898294},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,4,11]],"date-time":"2012-04-11T00:00:00Z","timestamp":1334102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p><jats:bold>Effects of Rhythm Control on Blood Pressure<\/jats:bold>.<\/jats:p><jats:p><jats:italic>Introduction:<\/jats:italic> The long\u2010term effects of atrial fibrillation (AF) on blood pressure (BP) in patients with hypertension (HTN) remain unclear. We hypothesized that restoration of normal sinus rhythm (NSR) results in a decrease in BP despite the expected increase in cardiac output.<\/jats:p><jats:p><jats:italic>Methods and Results:<\/jats:italic> Twenty\u2010four\u2010hour BP measurements were obtained during AF, and on Day 1 and Day 30 post\u2010successful cardioversion in 18 patients with AF and HTN (cardioversion group), and another 22 patients with AF and HTN with no immediate plans for cardioversion (control group). Except for the duration of AF, the clinical characteristics and use of medications were similar between the groups. In the cardioversion group, a significant decrease in diastolic blood pressure (DBP) and mean blood pressure (MBP) were noted on Day 1 post\u2010cardioversion with no significant change in systolic blood pressure (SBP): 117\/74\/88 \u00b1 13\/9\/9 mmHg during AF and 116\/70\/85 \u00b1 13\/9\/10 mmHg during Day 1 post\u2010cardioversion (P = 0.68; &lt;0.01 and 0.04 for SBP, DBP, and MBP, respectively). In the 13 subjects who remained in NSR at Day 30, DBP and MBP decreased further on Day 30 when compared to Day 1 with no significant change in SBP: 118\/76\/90 \u00b1 13\/7\/8 mmHg during AF; 119\/72\/88 \u00b1 12\/8\/9 mmHg during Day 1; and 118\/69\/86 \u00b1 10\/8\/7 mmHg during Day 30 post\u2010cardioversion (P = 0.97; &lt;0.001 and 0.03 for SBP, DBP, and MBP, respectively). In the control group, no significant changes in BP were noted.<\/jats:p><jats:p><jats:italic>Conclusion:<\/jats:italic> Restoring NSR in patients with AF and HTN resulted in a sustained decrease in DBP and MBP. To our knowledge, this is the first study to show that maintenance of NSR improves BP control in patients with AF and HTN. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 23, pp. 722\u2010726, July 2012)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8167.2011.02280.x","type":"journal-article","created":{"date-parts":[[2012,4,11]],"date-time":"2012-04-11T23:13:31Z","timestamp":1334186011000},"page":"722-726","source":"Crossref","is-referenced-by-count":15,"title":["Restoring Sinus Rhythm Results in Blood Pressure Reduction in Patients with Persistent Atrial Fibrillation and a History of Hypertension"],"prefix":"10.1111","volume":"23","author":[{"given":"NATALIE A.","family":"SANDERS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CRISTINA","family":"BERTOLONE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAWNI 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