{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T14:19:58Z","timestamp":1771510798247,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T00:00:00Z","timestamp":1334620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>PV Ablation for Persistent Atrial Fibrillation.\u2002<jats:italic>Introduction:<\/jats:italic> Effectiveness of antral pulmonary vein isolation (PVAI) and ablation of non\u2010PV triggers (non\u2010PVTA) in controlling longstanding persistent atrial fibrillation (AF) has not been reported. We sought to describe clinical outcomes with this ablation strategy in patients (pts) followed for at least 1 year.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic> Two hundred pts underwent PVAI for longstanding persistent AF and were followed for recurrence. Thirty\u2010three pts with &lt;1\u2010year follow\u2010up and 37 pts with additional RF atrial ablation were excluded, leaving 130 pts for analysis.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> All 130 pts (108 men, mean LA 4.7\u2003\u00b1\u20030.6 cm, mean AF duration of 38\u2003\u00b1\u200344 months) underwent PVAI with entrance\/exit block. In addition, 24 pts (15 pts during the initial procedure and 9 additional pts at repeat ablations) had 40 non\u2010PVTA, including 3 with AVNRT. During follow\u2010up, atrial flutter (AFL) was noted in 7 (5%) pts. The AF\u2010free survival after single procedure without antiarrhythmic drugs (AAD) was 38%. Repeat AF or AFL ablation was performed in 37 pts (28%) with PV reconnection uniformly identified (3.7\u2003\u00b1\u20030.5 veins\/pt). During mean follow\u2010up of 41.1\u2003\u00b1\u200323.8 months (range 12\u2013103 months), 85\/130 pts (65%) were in sinus rhythm with 65 pts (50%) off AAD, 20 pts (15%) on AAD. Additionally, 9 pts (7%) have had rare episodes of AF such that 72% of pts have had good long\u2010term clinical outcome. Of the 36 pts with recurrent AF, 20 pts have not had a repeat procedure.<\/jats:p><jats:p><jats:italic>Conclusions:<\/jats:italic> PVAI with non\u2010PVTA for longstanding persistent AF provides good long\u2010term AF control in over 70% of patients with infrequent (5%) AFL. AAD therapy and repeat PVAI may be required for this optimal outcome. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 23, pp. 806\u2010813, August 2012)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8167.2012.02307.x","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T16:10:51Z","timestamp":1334679051000},"page":"806-813","source":"Crossref","is-referenced-by-count":63,"title":["Pulmonary Vein Antral Isolation and Nonpulmonary Vein Trigger Ablation without Additional Substrate Modification for Treating Longstanding Persistent Atrial Fibrillation"],"prefix":"10.1111","volume":"23","author":[{"given":"DAVID","family":"LIN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID S.","family":"FRANKEL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ERICA S.","family":"ZADO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EDWARD","family":"GERSTENFELD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SANJAY","family":"DIXIT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID J.","family":"CALLANS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHAEL","family":"RILEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MATHEW","family":"HUTCHINSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FERMIN","family":"GARCIA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RUPA","family":"BALA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RALPH","family":"VERDINO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOSHUA","family":"COOPER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FRANCIS E.","family":"MARCHLINSKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,17]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000157153.30978.67"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2002.00971.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.00981.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.12.054"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.04524.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2010.01770.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.03503.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.21.2634"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.109.859116"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00940-9"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2007.09.024"},{"key":"e_1_2_7_13_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/europace\/eup349","article-title":"Does catheter ablation cure atrial fibrillation? 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