{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:49:49Z","timestamp":1784184589641,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,6,14]],"date-time":"2012-06-14T00:00:00Z","timestamp":1339632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p><jats:bold>Intrinsic QRS Narrowing with CRT<\/jats:bold>.\u2003<jats:italic>Background:<\/jats:italic> Cardiac resynchronization therapy (CRT) improves left ventricular ejection fraction (LVEF) in patients with congestive heart failure, LV systolic dysfunction, and a wide QRS complex. Previous reports suggest that CRT may also induce electrical remodeling but the impact on clinical outcome remains unknown.<\/jats:p><jats:p><jats:italic>Objective:<\/jats:italic> We sought to determine (1) if chronic CRT induces a relevant shortening of the intrinsic QRS (iQRS), (2) whether changes in the native conduction system correlate with clinical or echocardiographic response to CRT, and (3) to identify predictors of iQRS width shortening.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic> We prospectively included 85 consecutive patients with left bundle\u2010branch block who received a CRT device in 3 French centers. NYHA class, iQRS duration, LVEF, and left ventricular volumes were assessed before and 1 year after CRT implantation. Clinical and echocardiographic CRT responders were defined respectively as NYHA class improvement &gt;1 class without heart failure hospitalization and an increase of LVEF by \u226510% and\/or a decrease in LVESV by \u226515%. Electrocardiographic responders were defined as a decrease in iQRS duration by \u226520 ms.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> Baseline and 1\u2010year follow\u2010up mean iQRS durations were, respectively, 168.0\u2003\u00b1\u200319.7 ms and 149.6\u2003\u00b1\u200331.6 ms (P\u2003&lt;\u20030.0001). Electrocardiographic response, observed in 43\/85 patients (51%), was associated with a greater rate of clinical (P\u2003=\u20030.035) and echocardiographic (P\u2003=\u20030.023) response. Younger age, male gender, and longer baseline QRS width were independent predictors of electrocardiographic response.<\/jats:p><jats:p>Conclusion: CRT decreases iQRS duration. A reduction of at least 20 ms in iQRS duration is associated with better clinical and echocardiographic response. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 23, pp. 1219\u20131227, November 2012)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8167.2012.02376.x","type":"journal-article","created":{"date-parts":[[2012,5,15]],"date-time":"2012-05-15T17:56:38Z","timestamp":1337104598000},"page":"1219-1227","source":"Crossref","is-referenced-by-count":30,"title":["Reverse Electrical Remodeling by Cardiac Resynchronization Therapy: Prevalence and Clinical Impact"],"prefix":"10.1111","volume":"23","author":[{"given":"FREDERIC A.","family":"SEBAG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RAPHAEL 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