{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:24:42Z","timestamp":1792686282642,"version":"4.5.0"},"reference-count":9,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,6,26]],"date-time":"2012-06-26T00:00:00Z","timestamp":1340668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p><jats:bold>Atrial Flutter and Pulmonary Hypertension.<\/jats:bold>\u2003<jats:bold><jats:italic>Background:<\/jats:italic><\/jats:bold> Radiofrequency ablation is first\u2010line therapy for atrial flutter (AFL). There are no studies of ablation in patients with severe pulmonary arterial hypertension (PAH).<\/jats:p><jats:p><jats:bold>\n            <jats:italic>Methods:<\/jats:italic>\n          <\/jats:bold> Consecutive patients with severe PAH (systolic pulmonary artery pressure &gt;60 mmHg) and AFL referred for ablation were evaluated. Patients with complex congenital heart disease were excluded.<\/jats:p><jats:p><jats:bold>\n            <jats:italic>Results:<\/jats:italic>\n          <\/jats:bold> A total of 14 AFL ablation procedures were undertaken in 12 patients. A total of 75% of patients were female; mean age 49 \u00b1 12 years. SPAP prior to ablation was 99 \u00b1 35 mmHg. Baseline 6\u2010minute walk distance was 295 \u00b1 118 m. ECG demonstrated a typical AFL pattern in only 42% of cases. Baseline AFL cycle length was longer in PAH patients compared to controls (295 \u00b1 53 ms vs 252 \u00b1 35 ms, P = 0.006).<\/jats:p><jats:p>Cavotricuspid isthmus dependence was verified in 86% of cases. Acute success was obtained in 86% of procedures. SPAP decreased from 114 \u00b1 44 mmHg to 82 \u00b1 38 mmHg after ablation (P = 0.004). BNP levels were lower postablation (787 \u00b1 832 pg\/mL vs 522 \u00b1 745 pg\/mL, P = 0.02). Complications were seen in 14%. A total of 80% (8\/10) of patients were free of AFL at 3 months; 75% (6\/8) at 1 year.<\/jats:p><jats:p><jats:bold>\n            <jats:italic>Conclusion:<\/jats:italic>\n          <\/jats:bold> Ablation of AFL in severe PAH patients is feasible, with good short\u2010 and intermediate\u2010term success rates. The ECG pattern is not a reliable marker of isthmus dependence. The SPAP and BNP levels may decrease postablation. AFL may be a marker of poor outcomes in patients with PAH with a 1\u2010year mortality rate of 42% in this study. This rate is higher than expected in the general PAH population. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 23, pp. 1185\u20131190, November 2012)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8167.2012.02387.x","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T04:43:24Z","timestamp":1340772204000},"page":"1185-1190","source":"Crossref","is-referenced-by-count":29,"title":["Catheter Ablation of Typical Atrial Flutter in Severe Pulmonary Hypertension"],"prefix":"10.1111","volume":"23","author":[{"given":"JASON","family":"BRADFIELD","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHELLEY","family":"SHAPIRO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WILLIAM","family":"FINCH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RODERICK","family":"TUNG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NOEL G.","family":"BOYLE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ERIC","family":"BUCH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NILESH","family":"MATHURIA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RAVI","family":"MANDAPATI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KALYANAM","family":"SHIVKUMAR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MALCOLM","family":"BERSOHN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,26]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.01.004"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-5-343"},{"key":"e_1_2_7_4_2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1161\/CIRCULATIONAHA.109.898122","article-title":"Predicting survival in pulmonary arterial hypertension: Insights from the Registry to Evaluate Early and Long\u2010Term Pulmonary Arterial Hypertension Disease Management (REVEAL)","volume":"122","author":"Benza RL","journal-title":"Circulation"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp297"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.09.008"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90840-4"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.4.1233"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.109.871665"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.08.013"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8167.2012.02387.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8167.2012.02387.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T20:25:18Z","timestamp":1698697518000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8167.2012.02387.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,26]]},"references-count":9,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1540-8167.2012.02387.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8167.2012.02387.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,26]]}}}