{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T15:31:41Z","timestamp":1780673501119,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T00:00:00Z","timestamp":1345161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>Early Recurrence in STAR\u2010AF.<\/jats:p><jats:p><jats:italic>Background:<\/jats:italic> Early recurrences of atrial tachyarrhythmias (ERAT) are common after atrial fibrillation (AF) ablation, and predict late recurrences (LR). We sought to determine the impact of different ablation strategies on ERAT and LR.<\/jats:p><jats:p><jats:italic>Methods and Results:<\/jats:italic> The STAR\u2010AF trial randomized 100\u00a0 patients with paroxysmal or persistent AF to ablation of complex fractionated electrograms (CFAE) alone, pulmonary vein isolation (PVI) alone, or combined PVI\u00a0+ CFAE. Patients were followed for 12\u00a0 months. ERAT was defined as any recurrence of AF, atrial tachycardia, or flutter (AT\/AFL) &gt;30 seconds during the first 3\u00a0 months of follow\u2010up. LR was defined as any recurrence of AF\/AT\/AFL &gt;30 seconds 3\u201312\u00a0 months post. Forty\u2010nine patients experienced ERAT. The index ablation strategy was the only independent predictor of ERAT on multivariate analysis (HR 2.24 PVI vs PVI\u00a0+ CFAE; and HR 2.65 CFAE vs PVI\u00a0+ CFAE). Fifty\u2010two patients experienced LR. The presence of ERAT (HR 3.23), the use of antiarrhythmic drug (AAD) in the first 3\u00a0 months postablation (HR 2.85), and the index ablation strategy were independently associated with LR (HR 3.42 PVI vs PVI\u00a0+ CFAE; HR 4.72 CFAE vs PVI\u00a0+ CFAE). Thirty\u2010five of 49 (71%) patients with ERAT and 17 (33%) of 51\u00a0 patients without ERAT had LR (P\u00a0 &lt; 0.0001). Among patients with ERAT, increased left atrium size (HR 1.08), the use of AAD in the first 3\u00a0 months postablation (HR 2.86) and the index ablation strategy were independently associated with LR (HR 4.77 PVI vs PVI\u00a0+ CFAE; HR 4.45 CFAE vs PVI\u00a0+ CFAE).<\/jats:p><jats:p><jats:italic>Conclusion:<\/jats:italic> ERAT is common following AF ablation and is strongly associated with LR. Although CFAE ablation alone results in higher rates of early and LR, the addition of CFAE to PVI results in increased long\u2010term success without an increase in ERAT. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 23, pp. 1295\u20101301, December 2012)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8167.2012.02399.x","type":"journal-article","created":{"date-parts":[[2012,6,20]],"date-time":"2012-06-20T10:52:54Z","timestamp":1340189574000},"page":"1295-1301","source":"Crossref","is-referenced-by-count":60,"title":["Incidence and Significance of Early Recurrences Associated with Different Ablation Strategies for AF: A STAR\u2010AF Substudy"],"prefix":"10.1111","volume":"23","author":[{"given":"JASON 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