{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:23:03Z","timestamp":1778642583684,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,8,22]],"date-time":"2012-08-22T00:00:00Z","timestamp":1345593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p><jats:bold>Cost Effectiveness of MADIT\u2010CRT.<\/jats:bold>\u2002<jats:italic>Background:<\/jats:italic> The Multicenter Automatic Defibrillator Implantation Trial\u2010Cardiac Resynchronization Therapy (MADIT\u2010CRT) trial demonstrated that cardiac resynchronization therapy (CRT) when added to the implantable cardiac defibrillator (ICD) reduces risk of heart failure or death in minimally symptomatic patients with reduced cardiac ejection fraction and wide QRS complex.<\/jats:p><jats:p><jats:italic>Objectives:<\/jats:italic> To evaluate 4\u2010year cost\u2010effectiveness of CRT\u2010ICD compared to ICD alone using MADIT\u2010CRT data.<\/jats:p><jats:p><jats:italic>Research Design:<\/jats:italic> Patients enrolled in the trial were randomized to implantation of either ICD or CRT\u2010ICD in a 2:3 ratio, with up to 4\u2010year follow\u2010up period. Cost\u2010effectiveness analyses were conducted, and sensitivity analyses by age, gender, and left bundle branch block (LBBB) conduction pattern were performed.<\/jats:p><jats:p><jats:italic>Subjects:<\/jats:italic> A total of 1,271 patients with ICD or CRT\u2010ICD (US centers only) who reported healthcare utilization and health\u2010related quality of life data.<\/jats:p><jats:p><jats:italic>Measures:<\/jats:italic> We used the EQ\u20105D (US weights) to assess patient HRQOL and translated utilization data to costs using national Medicare reimbursement rates.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> Average 4\u2010year healthcare expenditures in CRT\u2010ICD patients were higher than costs of ICD patients ($62,600 vs 57,050, P = 0.015), mainly due to the device and implant\u2010related costs. The incremental cost\u2010effectiveness ratio of CRT\u2010ICD compared to ICD was $58,330\/quality\u2010adjusted life years (QALY) saved. The cost effectiveness improved with longer time horizon and for the LBBB subgroup ($7,320\/QALY), with no cost\u2010effectiveness benefit being evident in the non\u2010LBBB group.<\/jats:p><jats:p><jats:italic>Conclusions:<\/jats:italic> In minimally symptomatic patients with low ejection fraction and LBBB, CRT\u2010ICD is cost effective within 4\u2010year horizon when compared to ICD\u2010only. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 24, pp. 66\u201074, January 2013)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8167.2012.02413.x","type":"journal-article","created":{"date-parts":[[2012,8,22]],"date-time":"2012-08-22T14:49:28Z","timestamp":1345646968000},"page":"66-74","source":"Crossref","is-referenced-by-count":50,"title":["Cost\u2010Effectiveness of Cardiac Resynchronization Therapy in the MADIT\u2010CRT Trial"],"prefix":"10.1111","volume":"24","author":[{"given":"KATIA","family":"NOYES","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER","family":"VEAZIE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WILLIAM JACKSON","family":"HALL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HONGWEI","family":"ZHAO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"APRIL","family":"BUTTACCIO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KELLY","family":"THEVENET\u2010MORRISON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ARTHUR J.","family":"MOSS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,22]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192064"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032423"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050496"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq408"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906431"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009540"},{"key":"e_1_2_7_8_2","first-page":"729","article-title":"Reduction of the risk of recurring heart failure events with cardiac resynchronization therapy in the MADIT\u2010CRT trial","volume":"58","author":"Goldenberg I","year":"2011","journal-title":"Circulation"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.960898"},{"key":"e_1_2_7_10_2","unstructured":"Food and Drug Administration.Device approvals and clearances. Available at:http:\/\/www.fda.gov\/MedicalDevices\/ProductsandMedicalProcedures\/DeviceApprovalsandClearances\/default.htm(Accessed September 16 2010.2011)."},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp0904133"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.2005.00073.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.21.2129"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.032"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-200503000-00003"},{"key":"e_1_2_7_16_2","volume-title":"Cost\u2010Effectiveness in Health and Medicine","author":"Gold MR","year":"1996"},{"key":"e_1_2_7_17_2","first-page":"175","article-title":"Estimating mean quality adjusted lifetime with censored data","volume":"62","author":"Zhao H","year":"2000","journal-title":"Indian J Statistics"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2001.01002.x"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1191\/0962280202sm304ra"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/hec.903"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi662"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl382"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/hec.1093"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200017050-00005"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1258\/jhsrp.2008.008017"},{"issue":"8","key":"e_1_2_7_26_2","first-page":"iii","article-title":"Review of guidelines for good practice in decision\u2010analytic modelling in health technology assessment","author":"Philips Z","year":"2004","journal-title":"Health Technol Assess"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhealeco.2008.05.002"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-6296(96)00507-3"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1050(199902)8:1<25::AID-HEC398>3.0.CO;2-H"},{"key":"e_1_2_7_30_2","volume-title":"What Are Health Utilities?","author":"Tolley K.","year":"2009"},{"key":"e_1_2_7_31_2","volume-title":"Guide to the methods of technology appraisal","author":"National Institute for Health and Clinical Excellence","year":"2012"},{"key":"e_1_2_7_32_2","volume-title":"Methods for the Economic Evaluation of Health Care Programmes","author":"Drummond MF","year":"2005"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.14.1637"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.329.7459.224"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8167.2012.02413.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8167.2012.02413.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T16:56:18Z","timestamp":1697388978000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8167.2012.02413.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,22]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/j.1540-8167.2012.02413.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8167.2012.02413.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,22]]}}}