{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:52:47Z","timestamp":1789203167714,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,8,22]],"date-time":"2012-08-22T00:00:00Z","timestamp":1345593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>MRI Results of the MACPAF Study.\u2002<jats:bold><jats:italic>Background:<\/jats:italic><\/jats:bold> Left atrial catheter ablation (LACA) is an established therapeutic approach to abolish symptomatic atrial fibrillation (AF).<\/jats:p><jats:p><jats:bold>\n            <jats:italic>Objective:<\/jats:italic>\n          <\/jats:bold> Based on the prospective MACPAF study (clinicaltrials.gov NCT01061931) we report the rate of ischemic brain lesions postablation and their impact on cognitive function.<\/jats:p><jats:p><jats:bold>\n            <jats:italic>Methods:<\/jats:italic>\n          <\/jats:bold> Patients with symptomatic paroxysmal AF were randomized to LACA using the Arctic Front\u00ae or the HD Mesh Ablator\u00ae catheter. All patients underwent brain MRI at 3 Tesla, neurological, and neuropsychological examinations within 48 hours prior and after the ablation procedure.<\/jats:p><jats:p><jats:bold>\n            <jats:italic>Results:<\/jats:italic>\n          <\/jats:bold> There was no clinically evident stroke in 37 patients (mean age 62.4 \u00b1 8.4 years; 41% female; median CHADS2 score 1 [IQR 0\u20132]) after LACA but high\u2010resolution diffusion\u2010weighted imaging (DWI) detected new ischemic lesions in 15 (41%) patients after LACA. Four (27%) of the HD Mesh Ablator\u00ae patients and 11 (50%) of the Arctic Front\u00ae patients suffered a silent ischemic lesion (P = 0.19). In these 15 patients, there was a nonsignificant trend toward lower cardiac ejection fraction (P = 0.07) and AF episodes during LACA (P = 0.09), while activated clotting time levels, number of energy applications, periprocedural electrocardioversion or CHADS<jats:sub>2<\/jats:sub> score had no impact. Lesion volumes varied from 5 to 150 mm<jats:sup>3<\/jats:sup> and 1 to 5 lesions were detected per patient. However, acute brain lesions had no effect on cognitive performance immediately after LACA. Of the DWI lesions postablation 82% were not detectable on FLAIR images 6\u20139 months postablation.<\/jats:p><jats:p><jats:bold>\n            <jats:italic>Conclusions:<\/jats:italic>\n          <\/jats:bold> According to 3 Tesla high\u2010resolution DWI, ischemic brain lesions after LACA were common but not associated with impaired cognitive function after the ablation procedure. <jats:italic>(J Cardiovasc Electrophysiol, Vol. 24, pp. 14\u201021, January 2013)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8167.2012.02420.x","type":"journal-article","created":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T17:32:53Z","timestamp":1343237573000},"page":"14-21","source":"Crossref","is-referenced-by-count":81,"title":["3 Tesla MRI\u2010Detected Brain Lesions after Pulmonary Vein Isolation for Atrial Fibrillation: Results of the MACPAF Study"],"prefix":"10.1111","volume":"24","author":[{"given":"KARL 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