{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:54:42Z","timestamp":1789696482252,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T00:00:00Z","timestamp":1347321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>Electrical Delay in Apically Positioned LV Leads.\u2002<jats:italic>Introduction:<\/jats:italic> In recent studies, an anatomical apical left ventricular (LV) lead pacing location has been associated with deleterious outcome after cardiac resynchronization therapy (CRT). The differential impact of the LV lead electrical location in these patients remains unknown.<\/jats:p><jats:p><jats:italic>Methods and Results:<\/jats:italic> Thirty\u2010one consecutive CRT patients (mean age 71.7 \u00b1 12.7 years, 55% left bundle\u2010branch block [LBBB] morphology) with an apical LV lead and LV lead electrical delay (LVLED) were studied. Anatomical LV lead location was determined via review of coronary venography and chest radiographs. Electrical location was assessed through intraprocedural LVLED measurement. Patients were dichotomized into either \u201clong\u201d LVLED (LVLED \u2265 50% of QRS) or \u201cshort\u201d LVLED groups (LVLED &lt; 50%). Patients in the long LVLED group demonstrated significantly greater freedom from a primary composite endpoint of all\u2010cause death, heart failure hospitalization, and cardiac transplantation at 2 years (81% vs 30%, P = 0.007 vs short LVLED patients). Longer LVLED was also associated with more favorable LV remodeling (LV end\u2010systolic volume \u201341.9 \u00b1 10.3 mL vs \u20134.3 \u00b1 17.2 mL; P = 0.05), and greater improvement in LV ejection fraction (+9.4 \u00b1 2.9% vs +2.3 \u00b1 7.5%; P = 0.04). Even after multivariate adjustment, LVLED remained an independent predictor of the primary composite endpoint (HR 0.47, P = 0.031).<\/jats:p><jats:p><jats:italic>Conclusions:<\/jats:italic> Electrical lead localization, as estimated by LVLED \u2265 50%, is associated with improved long\u2010term clinical outcome and measures of LV remodeling in patients with apical LV leads. Intraprocedural LVLED assessment may provide incremental utility in targeting lead placement even in conventionally unfavorable anatomical segments.\u2002<jats:italic>(J Cardiovasc Electrophysiol, Vol. 24, pp. 182\u2010187, February 2013)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8167.2012.02428.x","type":"journal-article","created":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T02:04:29Z","timestamp":1343786669000},"page":"182-187","source":"Crossref","is-referenced-by-count":17,"title":["Electrical Delay in Apically Positioned Left Ventricular Leads and Clinical Outcome After Cardiac Resynchronization Therapy"],"prefix":"10.1111","volume":"24","author":[{"given":"JAGDESH","family":"KANDALA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GAURAV A.","family":"UPADHYAY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROBERT K.","family":"ALTMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ABHISHEK","family":"BOSE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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