{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:04:41Z","timestamp":1765728281403},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,20]],"date-time":"2005-06-20T00:00:00Z","timestamp":1119225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p> <jats:italic>This study is designed to evaluate the N\u2010terminal pro\u2010BNP (NTproBNP) levels in patients with mitral stenosis (MS) and its possible correlation with clinical and echocardiographic parameters of the disease. The study group consisted of 29 patients with isolated MS (patients with greater mild regurgitation were excluded) and 20 normal control subjects of similar age and gender distribution. Blood samples for NTproBNP were collected at the time of clinical and echocardiographic examination. NTproBNP levels were elevated in patients with MS compared to controls (325 \u00b1 249 pg\/dL [19.9\u2013890] versus 43 \u00b1 36 pg\/dL [5.76\u2013193.3], P &lt; 0.001). Patients with atrial fibrillation had significantly higher NTproBNP levels compared to those with sinus rhythm (561 \u00b1 281 pg\/dL versus 254 \u00b1 194 pg\/dL, P = 0.044). MS patients with sinus rhythm also had higher NTproBNP levels compared to controls (254 \u00b1 194 pg\/dL versus 43 \u00b1 36 pg\/dL, P = 0.00011). NT pro BNP levels correlated to the LA (R = 0.73, P &lt; 0.0001) and RV (R = 0.41, P = 0.042) diameters, mitral valve area (R =\u22120.45, P = 0.025), mean mitral gradient (R = 0.57, P = 0.003), peak PAP (R = 0.7, P = 0.03), and NYHA functional class (R = 0.61, P = 0.007). In conclusion, serum NTproBNP levels correlate well with echocardiographic findings and functional class in patients with MS and can be used as a marker of disease severity. Additionally, it may have a potential use as an additional noninvasive and relatively cheap method in monitoring disease progression especially in patients with poor echocardiographic windows.<\/jats:italic> <\/jats:p>","DOI":"10.1111\/j.1540-8175.2005.04085.x","type":"journal-article","created":{"date-parts":[[2005,6,20]],"date-time":"2005-06-20T19:13:58Z","timestamp":1119294838000},"page":"473-478","source":"Crossref","is-referenced-by-count":39,"title":["Serum N\u2010Terminal pro\u2010BNP Levels Correlate with Symptoms and Echocardiographic Findings in Patients with Mitral 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