{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T16:39:58Z","timestamp":1781023198477,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T00:00:00Z","timestamp":1153872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p> <jats:italic>Background: We recently reported the prevalence of aortic regurgitation (AR) by Doppler echocardiography (echo) in obese subjects to be higher than in some previous reports. Objective: To describe the prevalence of AR in an obese population not taking anorexigens as a function of demographic characteristics, cardiovascular risk factors, and other potential predictors. Methods: In 539 adult subjects, cardiovascular status was evaluated by medical history, physical examination, and Doppler echocardiograms performed according to a standardized imaging protocol. Echocardiographic readers were blinded as to each subject's medical and medication histories. Associations of AR with demographic and comorbid factors were examined. Results: Subjects had a mean (\u00b1 SD) body mass index (BMI) of 35 \u00b1 7 kg\/m<jats:sup>2<\/jats:sup>, and were predominantly white (87.6%), females (74%), with a mean age of 47 \u00b1 12 years. AR by Food and Drug Administration criteria (\u2265mild) was present in 4.1% of the subjects. Covariates significantly associated with AR were increasing age (P &lt; 0.001), presence of a history of hypertension (P = 0.001), left ventricular (LV) internal dimensions (P &lt; 0.005), and tricuspid and mitral regurgitation grade (P &lt; 0.001). Conclusions: Clinical and Doppler echo evaluation of a large, predominantly obese, adult population revealed that AR was more prevalent than in some previous reports and was highly correlated with increased age, presence of a history of hypertension, LV internal dimensions, tricuspid and mitral regurgitation.<\/jats:italic> <\/jats:p>","DOI":"10.1111\/j.1540-8175.2006.00278.x","type":"journal-article","created":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T15:37:43Z","timestamp":1153928263000},"page":"569-576","source":"Crossref","is-referenced-by-count":9,"title":["Aortic Valvular Regurgitation: Prevalence and Clinical Characteristics in a Predominantly Obese Adult Population Not Taking Anorexigens"],"prefix":"10.1111","volume":"23","author":[{"given":"Julius M.","family":"Gardin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginger","family":"Constantine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl L.","family":"Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,26]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"NIH:Clinical guidelines on the identification evaluation and treatment of overweight and obesity in adults [Executive summary]: NHLBI 1998."},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199809103391101"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00445-3"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-4-200102200-00009"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.17.2071"},{"key":"e_1_2_6_7_2","first-page":"355","article-title":"Clinical characteristics associated with aortic valvular regurgitation in a predominantly obese adult population [abstract]","volume":"12","author":"Gardin J","journal-title":"J Am Soc Echocardiogr"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.13.1703"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199809103391103"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00744-0"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(14)80105-3"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(87)80254-1"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.58.6.1072"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(97)00059-9"},{"key":"e_1_2_6_15_2","first-page":"208","volume-title":"The Analysis of Binary Data.","author":"Cox D","year":"1989"},{"key":"e_1_2_6_16_2","first-page":"I","article-title":"Prevalence and clinical correlates of aortic and mitral regurgitation in a young adult population [abstract]","volume":"90","author":"Reid C","year":"1994","journal-title":"Circulation"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)01064-9"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(14)80299-X"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.82.3.365"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.28.1.47"},{"key":"e_1_2_6_21_2","first-page":"23","article-title":"Echocardiography in the hypertensive heart: A new grading system to define the severity of the structural and functional changes","volume":"14","author":"Eren N","year":"1997","journal-title":"J Cardiovasc Diag Proc"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1159\/000175830"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(88)90378-5"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.21.2161"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01008-0"},{"key":"e_1_2_6_26_2","volume-title":"Pulmonary Vascular Physiology and Pathophysiology.","author":"Weir EK","year":"1989"},{"key":"e_1_2_6_27_2","unstructured":"AltmanPL DittmerDS:Respiration and Circulation. 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