{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:03:24Z","timestamp":1700438604141},"reference-count":94,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,7,2]],"date-time":"2007-07-02T00:00:00Z","timestamp":1183334400000},"content-version":"vor","delay-in-days":1674,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:p>Our current knowledge on the substrate and genesis of acute coronary syndromes (ACS) results from the integration of pathological, angiographic, and intracoronary imaging techniques. To summarize briefly the current paradigm, eight differentiated stages of development of atherosclerotic lesions are currently accepted, defined not only by the cellular elements involved but also by the appearance of sudden alterations of plaque structure and coronary thrombosis, The latter constitutes not only the dominant substrate for the most devastating manifestations of coronary artery disease, but also accelerates plaque size at a faster pace than in earlier stages. The composition of atherosclerotic plaque varies significantly along the different evolutive stages, and thus includes cellular (macrophage, smooth muscle cells) and noncellular elements (glicosamingtycan or collagen\u2010rich cellular matrix, extracellular lipid deposits, calcification, fresh, or organized thrombus) in a varying proportion. Furthermore, a dynamic process of vessel remodeling occurs along the atherosclerotic process, resulting, in most cases, in a protective mechanism against myocardial ischemia by preserving luminal dimensions during plaque enlargement. Intravascular ultrasound (IVUS) is one of the intracoronary imaging techniques that has contributed to the understanding of these changes in man. In addition. IVUS has the potential of being a useful clinical tool for predicting the chances of future acute coronary events by identifying vulnerable plaques, of characterizing which is the culprit lesion in ACS, and in guiding revascularization procedures in the treacherous field of thrombotic coronary syndromes. In this article, we review the current evidence on the potential of IVUS imaging for fulfilling these purposes.<\/jats:p>","DOI":"10.1111\/j.1540-8183.2002.tb01088.x","type":"journal-article","created":{"date-parts":[[2007,7,2]],"date-time":"2007-07-02T09:30:16Z","timestamp":1183368616000},"page":"447-459","source":"Crossref","is-referenced-by-count":1,"title":["<b>Intracoronary Ultrasound in Acute Coronary Syndromes<\/b>: From Characterization of Vulnerable Plaques to Guidance of Percutaneous Treatment of Complex Stenoses"],"prefix":"10.1111","volume":"15","author":[{"given":"JES\u00daS","family":"JIMENEZ","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAVIER","family":"ESCANED","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,7,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(91)90389-3"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00381-0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.50.2.127"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.3.657"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.69.5.377"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.5.1084"},{"key":"e_1_2_1_8_2","first-page":"663","article-title":"Plaque size, vessel size, and plaque vulnerability. Bigger may not be better","volume":"32","author":"Shah PK","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198405033101801"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80161-3"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)90482-G"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(79)90248-0"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00737168"},{"key":"e_1_2_1_14_2","first-page":"319","article-title":"The coronary arteries in cases of cardiac and non\u2010cardiac sudden death","volume":"132","author":"Cliff WJ","year":"1988","journal-title":"Am J Pathol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90953-7"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(98)70207-8"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.3.913"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.5.1575"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1996.0433"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90471-3"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90667-P"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.85.5.567"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90714-C"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.81.6.621"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01234-7"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01097-4"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00533-1"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198705283162204"},{"key":"e_1_2_1_29_2","first-page":"1","article-title":"Arterial remodeling in stable versus unstable coronary syndromes: An intravascular ultrasound study","volume":"98","author":"Schoenhagen P","year":"1998","journal-title":"Circulation"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00304-0"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.6.598"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02282-8"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.6.1408"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90282-8"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)91789-W"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.1.109"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.4.604"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8651(05)70076-X"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)90993-B"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(96)00201-3"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870110706"},{"key":"e_1_2_1_42_2","first-page":"123","article-title":"Ultrasound tissue characterization techniques in evaluation plaque structure","volume":"8","author":"Picano E","year":"1994","journal-title":"Am J Card Imaging"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2000.109217"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000017200.47342.10"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.79.5.459"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.6.617"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2001.2806"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00320-3"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.5.4.336"},{"key":"e_1_2_1_50_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1001\/jama.1994.03510280051032","article-title":"Remodeling of coronary arteries in human and nonhuman primates","volume":"271","author":"Clakson TB","year":"1994","journal-title":"JAMA"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.5.1444"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)91007-5"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90931-8"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.7.1791"},{"key":"e_1_2_1_55_2","first-page":"1353","article-title":"Predictors of coronary arterial remodeling patterns in patients with myocardial ischemia","volume":"80","author":"Taught J","year":"1997","journal-title":"Am J Cardiol"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.10.1818"},{"key":"e_1_2_1_57_2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/0741-5214(88)90433-8","article-title":"Differential enlargement of artery segments in response to enlarging atherosclerotic plaques","volume":"7","author":"Zarins CK","year":"1988","journal-title":"J Vase Surg"},{"key":"e_1_2_1_58_2","first-page":"124A","article-title":"Patient and plaque characteristics associated with coronary artery remodeling: An intravascular ultrasound study, (abstract)","volume":"29","author":"Weissmann NJ","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"e_1_2_1_59_2","first-page":"365A","article-title":"Insulin dependence blunts the adaptative remodeling response to plaque accumulation in diabetes mellitus: An intravascular ultrasound study (abstract)","volume":"29","author":"Kornowski R","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"e_1_2_1_60_2","first-page":"I\u2013604","article-title":"Influence of plaque morphology on the development of coronary remodeling: An intravascular ultrasound study, (abstract)","volume":"94","author":"Fujii T","year":"1996","journal-title":"Circulation"},{"key":"e_1_2_1_61_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.5.966"},{"key":"e_1_2_1_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(88)90356-7"},{"key":"e_1_2_1_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00184-7"},{"key":"e_1_2_1_64_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.71.4.850"},{"key":"e_1_2_1_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(93)90039-W"},{"key":"e_1_2_1_66_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.82.1.68"},{"key":"e_1_2_1_67_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.82.4.461"},{"key":"e_1_2_1_68_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.84.3.314"},{"key":"e_1_2_1_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90670-X"},{"key":"e_1_2_1_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(95)90387-9"},{"key":"e_1_2_1_71_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.5.2026"},{"key":"e_1_2_1_72_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.6.1676"},{"key":"e_1_2_1_73_2","first-page":"I\u2013795","article-title":"The antiplatelet treatment after intravascular ultrasound\u2010guided optimal expansion (APLAUSE) trial","volume":"92","author":"Wong SC","year":"1995","journal-title":"Circulation"},{"key":"e_1_2_1_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)00366-X"},{"key":"e_1_2_1_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(96)90579-2"},{"key":"e_1_2_1_76_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.7.1959"},{"key":"e_1_2_1_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)80017-B"},{"key":"e_1_2_1_78_2","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1093\/oxfordjournals.eurheartj.a060784","article-title":"Mechanisms of luminal enlargement and quantification of vessel wall trauma following balloon coronary angioplasty and directional atherectomy","volume":"11","author":"Baptista J","year":"1995","journal-title":"Eur Heart J"},{"key":"e_1_2_1_79_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.8.2044"},{"key":"e_1_2_1_80_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.24.3149"},{"key":"e_1_2_1_81_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.1.35"},{"issue":"4","key":"e_1_2_1_82_2","first-page":"I","article-title":"IVUS\u2010determined predictors of restenosis in PTCA and DCA: An interim report from the GUIDE trial, phase II. (abstract)","volume":"90","author":"The GUIDE trial investigators.","year":"1994","journal-title":"Circulation"},{"key":"e_1_2_1_83_2","first-page":"I\u2013148","article-title":"Intravascular ultrasound variables predict restenosis after PTCA","volume":"92","author":"G\u00f6rg\u00eb G","year":"1995","journal-title":"Circulation"},{"key":"e_1_2_1_84_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.9.2254"},{"key":"e_1_2_1_85_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.9.2997"},{"key":"e_1_2_1_86_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.5.523"},{"key":"e_1_2_1_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01145-7"},{"key":"e_1_2_1_88_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2001.115793"},{"key":"e_1_2_1_89_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.20.2497"},{"key":"e_1_2_1_90_2","unstructured":"RussoRJ NicosiaA Teistein PS for the AVID investigators. Angiography Versus Intravascular Ultrasound\u2010directed Stent Placement. (abstract)J Am Coll Cardiol1997:61A."},{"key":"e_1_2_1_91_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3701.096064"},{"key":"e_1_2_1_92_2","first-page":"I\u2013545","article-title":"Acute and late clinical and angiographic results of directional atherectomy in the Optimal Atherectomy Restenosis Study (OARS)","volume":"92","author":"Simonton CA","year":"1995","journal-title":"Circulation"},{"key":"e_1_2_1_93_2","unstructured":"SumitsugiS SuzukiT KatohO et al.Restenosis mechanism after aggressive directional coronary atherectomy assessed by intravascular ultrasound in Adjunctive Balloon Angioplasty following Coronary Atherectomy Study (ABACAS). The ABACAS investigators (abstract).J Am Coll Cardiol1997;129A."},{"key":"e_1_2_1_94_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0304(199810)45:2<131::AID-CCD6>3.0.CO;2-D"},{"key":"e_1_2_1_95_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4501.099317"}],"container-title":["Journal of Interventional Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8183.2002.tb01088.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8183.2002.tb01088.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T12:40:05Z","timestamp":1700397605000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8183.2002.tb01088.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12]]},"references-count":94,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["10.1111\/j.1540-8183.2002.tb01088.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8183.2002.tb01088.x","archive":["Portico"],"relation":{},"ISSN":["0896-4327","1540-8183"],"issn-type":[{"value":"0896-4327","type":"print"},{"value":"1540-8183","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12]]}}}