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Current antiplatelet agents are designed to inhibit various mediators of platelet activation, such as thromboxane A2 and adenosine diphosphate, and platelet\u2010surface receptors (e.g., glycoprotein IIb\/IIIa receptors). The rationale for upstream versus deferred administration of antiplatelet therapy in patients scheduled for percutaneous intervention and the current ACC\/AHA guidelines for the management of patients with unstable angina\/non\u2010ST\u2010segment myocardial infarction are discussed. The next\u2010generation antiplatelet drugs are in various stages of clinical development, with unique differentiating mechanistic and pharmacokinetic properties. The newer P2Y12 thienopyridine receptor antagonists and protease receptor inhibitor are also examined, in addition to the rationale of various outcome studies evaluating the efficacy and safety of the different agents.<\/jats:italic> <\/jats:p>","DOI":"10.1111\/j.1540-8183.2008.00409.x","type":"journal-article","created":{"date-parts":[[2008,11,25]],"date-time":"2008-11-25T14:28:16Z","timestamp":1227623296000},"source":"Crossref","is-referenced-by-count":5,"title":["Advances in Antiplatelet Therapy for ACS and PCI"],"prefix":"10.1111","volume":"21","author":[{"given":"DAVID J.","family":"MOLITERNO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,11,25]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)90479-6"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02833-4"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198308183090703"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198511283132201"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198810273191701"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92336-G"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7329.71"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.01.049"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200060020-00012"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl275"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.04.090"},{"key":"e_1_2_7_13_2","unstructured":"Available athttp:\/\/www.clinicaltrials.gov. 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