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The DES was prepared by spray coating a bare metal stent with a biodegradable polymer loaded with sirolimus and triflusal, to treat against restenosis and thrombosis, respectively. The two\u2010layered dual drug\u2010coated stent was characterized in vitro for surface properties before and after expansion, as well as for possible delamination by cross\u2010sectioning the stent in vitro. In vivo animal studies (in a pig model) were then performed for acute thrombosis, inflammation, and restenosis. The results show a significant reduction in restenosis with a stent coated with both drugs compared with the controls (a bare metal stent, a sirolimus\u2010coated, and a pure polymer\u2010coated stent). The reduction in restenosis with a sirolimus\/triflusal\u2010eluting stent is associated with an inhibition of inflammation and thrombus formation, suggesting that such dual DES have a role to play for the treatment of coronary artery diseases.<\/jats:italic> <\/jats:p>","DOI":"10.1111\/j.1540-8183.2009.00489.x","type":"journal-article","created":{"date-parts":[[2009,7,14]],"date-time":"2009-07-14T01:39:49Z","timestamp":1247535589000},"page":"466-478","source":"Crossref","is-referenced-by-count":17,"title":["The Short\u2010Term Effect on Restenosis and Thrombosis of a Cobalt\u2010Chromium Stent Eluting Two Drugs in a Porcine Coronary Artery Model"],"prefix":"10.1111","volume":"22","author":[{"given":"YINGYING","family":"HUANG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUBBU S.","family":"VENKATRAMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FREDDY Y. 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