{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:39:35Z","timestamp":1791355175290,"version":"4.3.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T00:00:00Z","timestamp":1323302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p><jats:bold>\n            <jats:italic>Background:<\/jats:italic>\n          <\/jats:bold>\n          <jats:italic>Limited prospectively collected data are available on the total outcomes, cost estimates, and quality of life associated with treatment of acute coronary syndrome (ACS) through 1 year in a nonclinical\u2010trial setting, or on the impact of new clinical events by 1 year on resource utilization and costs.<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Methods:<\/jats:italic>\n          <\/jats:bold>\n          <jats:italic>The Antiplatelet Therapy Observational Registry (APTOR) 12\u2010month study followed 1,335 concurrently recruited ACS patients undergoing percutaneous coronary intervention (PCI) and treated with antiplatelet therapy from France, Spain, and the United Kingdom in a \u201creal world\u201d clinical setting. Data were collected on clinical events, resource utilization, quality of life, and cost estimates through 1\u2010year follow\u2010up.<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Results:<\/jats:italic>\n          <\/jats:bold>\n          <jats:italic>By 1 year, 14.4% (95% CI 12.7\u201316.4%) of patients experienced a clinical event of death, MI, stroke, unstable angina, urgent target vessel revascularization, or acute heart failure. Costs by 1 year were higher among those who had a new clinical event (\u00a38,988, 95% CI \u00a37,848, \u00a310,395) as compared with those with no events (\u00a35,809, 95% CI \u00a35,486, \u00a36,161). This increased cost was due to higher postdischarge resource use costs. Using the EQ\u20105D assessment at 1 year, quality of life was directionally lower in those patients who had experienced a new clinical event.<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Conclusions:<\/jats:italic>\n          <\/jats:bold>\n          <jats:italic>The risk of experiencing a new clinical event during the year following an ACS, which was treated with PCI, remains high among European patients, with one\u2010seventh of patients having a new event. These additional clinical outcomes reduce quality of life and increase health care expenditures, expanding the already high cost of treatment for ACS.<\/jats:italic> (J Interven Cardiol 2012;25:19\u201327)<\/jats:p>","DOI":"10.1111\/j.1540-8183.2011.00690.x","type":"journal-article","created":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T12:52:28Z","timestamp":1323348748000},"page":"19-27","source":"Crossref","is-referenced-by-count":10,"title":["Clinical Outcomes, Resource Use, and Costs at 1 Year in Patients with Acute Coronary Syndrome Undergoing PCI: Results from the Multinational APTOR Registry"],"prefix":"10.1111","volume":"25","author":[{"given":"AMEET","family":"BAKHAI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JEAN","family":"FERRIERES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANDRES","family":"I\u00d1IGUEZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAGALI","family":"SARTRAL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARK","family":"BELGER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CLAUDE","family":"SCHMITT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"UWE","family":"ZEYMER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on Behalf of APTOR Trial Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,8]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X167462"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.181940"},{"key":"e_1_2_7_4_2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1161\/CIRCULATIONAHA.107.188209","article-title":"Focused update of the ACC\/AHA 2004 guidelines for the management of patients with ST\u2010elevation myocardial infarction: A report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines: Developed in collaboration with the Canadian Cardiovascular Society endorsed by the American Academy of Family Physicians: 2007 Writing Group to review new evidence and update the ACC\/AHA 2004 guidelines for the management of patients with ST\u2010elevation myocardial infarction, writing on behalf of the 2004 Writing Committee","volume":"117","author":"Antman EM","year":"2007","journal-title":"Circulation"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm161"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn416"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq277"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.900704"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.13.1711"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.02.044"},{"key":"e_1_2_7_11_2","first-page":"307","article-title":"Cost of care for new\u2010onset acute coronary syndrome patients who undergo coronary revascularization","volume":"17","author":"McCollam P","year":"2005","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1185\/03007990903479331"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2010.488882"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1185\/030079908X261096"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2010.509257"},{"key":"e_1_2_7_16_2","unstructured":"National Institute for Health and Clinical Excellence (NICE). 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