{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:00:00Z","timestamp":1761102000962},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T00:00:00Z","timestamp":1331510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p><jats:bold>\n            <jats:italic>Background:<\/jats:italic>\n          <\/jats:bold>\n          <jats:italic>Controversy exists about the impact of treating bifurcations on overall outcome of coronary interventions using drug\u2010eluting stents (DES). We sought to investigate 1\u2010year outcome of the treatment of bifurcation lesions using DES in a large \u201creal\u2010world\u201d cohort.<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Methods and Results:<\/jats:italic>\n          <\/jats:bold>\n          <jats:italic>Among 5,126 patients enrolled in phase I of the multicenter German Drug\u2010Eluting Stent Registry, 814 (16%) were treated for a bifurcation lesion. Patients with bifurcations were compared to those without bifurcations in terms of baseline characteristics, major adverse cardiac and cerebrovascular events (MACCE) and target vessel revascularization (TVR) at 1 year. Usage of sirolimus\u2010eluting stents (SES) versus paclitaxel\u2010eluting stents (PES) was also evaluated. In total, 1,021 and 5,189 stents were implanted in the bifurcation (1.25 stents\/patient) and nonbifurcation (1.2 stents\/patient) group, respectively, but 64.5% of bifurcation lesions were treated with a single stent. More complex lesion and procedural characteristics were observed in the bifurcation group. However, there was no difference in 1\u2010year MACCE rates (a composite of death, myocardial infarction, and stroke) between the bifurcation group and nonbifurcation group (8.1% vs. 8.3%, P = 0.85). Rates of TVR (11.2% vs. 10.8%, P = 0.75) and Academic Research Consoritum\u2010defined definite stent thrombosis (0.9% vs. 0.8%, P = 0.67) were also comparable. MACCE and TVR rates remained similar after adjustment for differences in baseline characteristics. MACCE and TVR in SES patients were 7.2% and 12.6% versus 8.7% and 10.2% in PES patients (P = 0.46 and P = 0.30, respectively).<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Conclusion:<\/jats:italic>\n          <\/jats:bold>\n          <jats:italic>In this large multicenter registry, treatment of bifurcation lesions with DES appears effective and safe. The presence of bifurcations did not affect 1\u2010year outcomes after DES implantation. The outcomes for SES and PES were similar.<\/jats:italic> (J Interven Cardiol 2012;25:344\u2013352)<\/jats:p>","DOI":"10.1111\/j.1540-8183.2011.00718.x","type":"journal-article","created":{"date-parts":[[2012,3,13]],"date-time":"2012-03-13T01:08:19Z","timestamp":1331600899000},"page":"344-352","source":"Crossref","is-referenced-by-count":4,"title":["Treatment of Coronary Bifurcation Lesions with Drug\u2010Eluting Stents: Insights from the First Phase of the Prospective Multicenter German Drug\u2010Eluting Stent Registry"],"prefix":"10.1111","volume":"25","author":[{"given":"MOHAMED","family":"ABDEL\u2010WAHAB","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRISTOPH A.","family":"NIENABER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AHMAD 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