{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T15:17:53Z","timestamp":1775834273044,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T00:00:00Z","timestamp":1339027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p><jats:bold>\n            <jats:italic>Objectives:<\/jats:italic>\n          <\/jats:bold>\u2002<jats:italic>The aim of this study was to assess whether transient atrial septal defect (ASD) occlusion and, if required, vasodilator therapy would improve the safety of percutaneous ASD closure in high\u2010risk subsets.<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Background:<\/jats:italic>\n          <\/jats:bold>\u2002<jats:italic>While percutaneous ASD closure is generally considered a low risk intervention, hypertensive and elderly patients may develop pulmonary edema following the procedure because of underlying left ventricular (LV) diastolic dysfunction.<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Methods:<\/jats:italic>\n          <\/jats:bold>\u2002<jats:italic>Fifty\u2010two consecutive patients who underwent successful percutaneous ASD closures were enrolled into a single\u2010center prospective registry. Patients with arterial hypertension and\/or &gt;60 years of age (n = 15) were considered at risk for periprocedural pulmonary edema. Those patients were tested for an increase of LV filling pressures during transient ASD occlusion and, if this was the case, treated according to a prespecified algorithm. Clinical and echocardiography data were collected in\u2010hospital and at 6 months follow\u2010up.<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Results:<\/jats:italic>\n          <\/jats:bold>\u2002<jats:italic>Shunt size was comparable in high and standard\u2010risk patients (Qp:Qs 2.1 \u00b1 0.8 vs. 2.1 \u00b1 0.7, P = 0.82). High\u2010risk patients had more often pulmonary hypertension (58% vs. 14%, P &lt; 0.05) and were more frequently symptomatic. Among them, 4\/15 (27%) demonstrated a significant rise of left\u2010sided filling pressures during transient ASD balloon occlusion and underwent pharmacologic preconditioning prior to ASD closure. None of them developed periprocedural pulmonary edema. At follow\u2010up, patients were less symptomatic (Pre: NYHA II n = 15, NYHA III n = 9; Post: NYHA II n = 15, NYHA III n = 0; P = 0.02) and right ventricular size decreased from 23 \u00b1 5 cm<jats:sup>2<\/jats:sup> to 17 \u00b1 5 cm<jats:sup>2<\/jats:sup>, P &lt; 0.05.<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Conclusion:<\/jats:italic>\n          <\/jats:bold>\u2002<jats:italic>Transient ASD occlusion and, if required, pharmacologic preconditioning prior to percutaneous closure may prevent periprocedural pulmonary edema in high\u2010risk patients.<\/jats:italic> (J Interven Cardiol 2012;25:505\u2013512)<\/jats:p>","DOI":"10.1111\/j.1540-8183.2012.00747.x","type":"journal-article","created":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T07:31:10Z","timestamp":1339054270000},"page":"505-512","source":"Crossref","is-referenced-by-count":13,"title":["Pharmacologic Preconditioning Therapy Prior to Atrial Septal Defect Closure in Patients at High Risk for 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R.","family":"EBERLI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,7]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.02.051"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01862-4"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.06.086"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.06.008"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.10.030"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.10.018"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2007.10.013"},{"key":"e_1_2_7_9_2","first-page":"173","article-title":"Transcatheter device closure of atrial septal defects in patients older than 60 years of age: Immediate and follow\u2010up 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