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Emergence of resistant strains of Propionibacterium acnes, adverse events, and compliance issues associated with chronic systemic tetracycline use have led to new treatment approaches. At subantimicrobial doses, tetracyclines reduce inflammation via anticollagenolytic, antimatrix\u2010degrading metalloproteinase, and cytokine down\u2010regulating properties. Subantimicrobial dose (SD) doxycycline (Periostat 20 mg) has clinical utility in periodontitis and has been investigated in a double\u2010blind, placebo\u2010controlled trial in the treatment of moderate facial acne as well as in an open label study in the treatment of rosacea. The results of subantimicrobial dose doxycycline treatment in early trials support its benefits and further investigation in acne and rosacea.<\/jats:italic> <\/jats:p>","DOI":"10.1111\/j.1540-9740.2003.03014.x","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T12:24:02Z","timestamp":1182428642000},"page":"234-246","source":"Crossref","is-referenced-by-count":55,"title":["Subantimicrobial Dose Doxycycline for Acne and Rosacea"],"prefix":"10.1111","volume":"2","author":[{"given":"Bikowski","family":"Joseph B.","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,21]]},"reference":[{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704173361607"},{"issue":"200","key":"e_1_2_14_3_2","article-title":"Current estimates from the National Health Interview Survey, 1996","volume":"10","author":"Adams PF","year":"1999","journal-title":"Vital Health Stat"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)80056-5"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.110901"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90421-2"},{"key":"e_1_2_14_7_2","first-page":"156","article-title":"Women commonly seek care for rosacea: dermatologists frequently provide the care","volume":"68","author":"Feldman SR","year":"2001","journal-title":"Cutis"},{"key":"e_1_2_14_8_2","first-page":"3","article-title":"Rosacea: a tiered approach to therapy","volume":"66","author":"Bikowski JB","year":"2000","journal-title":"Cutis"},{"key":"e_1_2_14_9_2","first-page":"419","article-title":"An epidemiological study of rosacea","volume":"69","author":"Berg M","year":"1989","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006205-199710000-00005"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)01046-0"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690030091015"},{"key":"e_1_2_14_13_2","first-page":"29","article-title":"Pathogenesis of rosacea","volume":"17","author":"Dahl MV","year":"2001","journal-title":"Adv Dermatol"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.21.5.770"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000017847"},{"key":"e_1_2_14_16_2","first-page":"411","article-title":"Second\u2010generation tetracyclines, a dermatologic overview: clinical uses and pharmacology","volume":"48","author":"Maibach H","year":"1991","journal-title":"Cutis"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.6.679"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1975.tb02252.x"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1998.tb140250.x"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(83)70005-8"},{"key":"e_1_2_14_21_2","first-page":"22","article-title":"Antibiotic sensitivity of Propionibacterium acnes isolates from patients with acne vulgaris in a tertiary dermatological referral centre in Singapore","volume":"30","author":"Tan HH","year":"2001","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1159\/000017869"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12676385"},{"key":"e_1_2_14_24_2","first-page":"381","article-title":"Antibiotic resistant propionibacteria and acne: crisis or conundrum? 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