{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T12:57:36Z","timestamp":1697201856336},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T00:00:00Z","timestamp":1182384000000},"content-version":"vor","delay-in-days":1146,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skinmed"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p> <jats:italic>This review is intended as an update on modern trends in the global impact and epidemiology of human immunodeficiency virus infection for physicians who are not acquired immunodeficiency syndrome experts. Africa has been the most affected, but epidemics are spreading in Asia and Russia. Therefore, physicians should be informed about seroconversion disease and human immunodeficiency virus diagnosis as well as the impact of sexually transmitted infections on many stages of human immunodeficiency virus. International treatment guidelines are available. Highly active antiretroviral therapy has been the mainstream therapy since 1996, but all drugs\u2014regardless of class used\u2014have potent side effects, many of which are dermatologic. Others affect the neurologic, hematopoietic, cerebral, and abdominal systems, and drug interactions are common. Lipodystrophy is a common, long\u2010term side effect that is still not well understood. Broader use of highly active antiretroviral therapy has highlighted viral resistance. This is reviewed, and a simple explanation of therapeutic monitoring is provided.<\/jats:italic> <\/jats:p>","DOI":"10.1111\/j.1540-9740.2004.02304.x","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T12:14:06Z","timestamp":1182428046000},"page":"149-156","source":"Crossref","is-referenced-by-count":5,"title":["HIV Revisited: The Global Impact of the HIV\/AIDS Epidemic"],"prefix":"10.1111","volume":"3","author":[{"given":"Evans","family":"Amy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Rachel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mammen\u2010Tobin","family":"Amy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piyadigamage","family":"Anura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shann","family":"Siobhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waugh","family":"Michael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,21]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"22","volume-title":"Report on the Global HIV\/AIDS Epidemic 2002","author":"United Nations Children's Fund; United Nations Development Fund; United Nations Population Fund; United Nations Educational, Scientific, and Cultural Organization; World Health Organization; World Bank","year":"2002"},{"key":"e_1_2_6_3_2","volume-title":"A Glance at the HIV Epidemic","year":"2001"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-125-4-199608150-00001"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-125-4-199608150-00001"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200205240-00005"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.18.2417"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/sti.75.1.3"},{"key":"e_1_2_6_9_2","first-page":"659","article-title":"Human papilloma virus infections in women with HIV disease: prevalence, risk, and management","volume":"10","author":"Jay N","year":"2000","journal-title":"AIDS Read"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707313370504"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707313370504"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/sti.78.4.235"},{"key":"e_1_2_6_13_2","article-title":"Kaiser Family Foundation Panel on Clinical Practices for Treatment of HIV Infection","author":"Department Of Health","journal-title":"Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents"},{"issue":"2","key":"e_1_2_6_14_2","first-page":"S3","article-title":"NNRTI hepatotoxicity: efavirenz versus nevirapine","volume":"7","author":"Pulido F","year":"2002","journal-title":"J HIV Ther"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8019.2000.00032.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8019.2000.00032.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199807000-00003"},{"key":"e_1_2_6_18_2","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1097\/00002030-199909100-00009","article-title":"A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long\u2010term nucleoside analogue therapy","volume":"13","author":"Saint\u2010Marc T","year":"1999","journal-title":"AIDS"},{"issue":"9256","key":"e_1_2_6_19_2","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S0140-6736(00)04056-3","article-title":"Risk of lipodystrophy in HIV\u20101 infected patients treated with protease inhibitors: a prospective cohort study","volume":"357","author":"Martinez E","year":"2001","journal-title":"Lancet"},{"issue":"1","key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/00126334-200209010-00007","article-title":"Abnormalities of body fat distribution in HIV\u2010infected persons treated with antiretroviral drugs: The Swiss HIV Cohort Study","volume":"31","author":"Bernasconi E Boubaker K","year":"2002","journal-title":"J Acquir Immune Defic Syndr"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200209010-00007"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08468-2"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200124030-00001"},{"key":"e_1_2_6_24_2","volume-title":"Program and Abstracts of the First International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV","author":"Engelson ES","year":"1999"},{"key":"e_1_2_6_25_2","volume-title":"Program and Abstracts of the 10th Conference on Retroviruses and Opportunistic Infections","author":"Fris\u2010Moller N"},{"key":"e_1_2_6_26_2","volume-title":"Program and Abstracts of the Sixth Conference on Retroviruses and Opportunistic Infections","author":"Saint\u2010Marc T"},{"issue":"3","key":"e_1_2_6_27_2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/00002030-200202150-00021","article-title":"Avascular necrosis of the bone in HIV\u2010infected patients: incidence and associated factors","volume":"16","author":"Gutierez F","year":"2002","journal-title":"AIDS"},{"issue":"14","key":"e_1_2_6_28_2","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1097\/00002030-200109280-00014","article-title":"Nevirapine and the risk of Stevens\u2010Johnson syndrome or toxic epidermal necrolysis","volume":"15","author":"Fagot JP","year":"2001","journal-title":"AIDS"},{"key":"e_1_2_6_29_2","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1097\/00002030-199911120-00016","article-title":"Prednisolone does not prevent the occurrence of nevirapineinduced rashes","volume":"13","author":"Rey D","year":"1999","journal-title":"AIDS"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199905280-00022"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803263381301"},{"key":"e_1_2_6_32_2","volume-title":"Eighth Conference on Retroviruses and Opportunistic Infections","author":"Greub G"},{"key":"e_1_2_6_33_2","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1016\/S0140-6736(98)12291-2","article-title":"Drug resistance genotyping in HIV\u20101 therapy; the Viradapt randomised controlled trial","volume":"353","author":"Durant J","year":"1999","journal-title":"Lancet"},{"key":"e_1_2_6_34_2","doi-asserted-by":"crossref","first-page":"F83","DOI":"10.1097\/00002030-200006160-00001","article-title":"A randomised study of antiretroviral management based on plasma genotypic antiretroviral resistance testing in patients failing therapy","volume":"14","author":"Baxter JD","year":"2000","journal-title":"AIDS"},{"issue":"1","key":"e_1_2_6_35_2","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1097\/00042560-200103011-00006","article-title":"Clinical utility of resistance testing: retrospective and prospective data supporting use and current recommendations","volume":"26","author":"Haubrich R","year":"2001","journal-title":"J Acquir Immune Defic Syndr"}],"container-title":["SKINmed: Dermatology for the Clinician"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-9740.2004.02304.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-9740.2004.02304.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/j.1540-9740.2004.02304.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-9740.2004.02304.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T22:22:56Z","timestamp":1694384576000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-9740.2004.02304.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1111\/j.1540-9740.2004.02304.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-9740.2004.02304.x","archive":["Portico"],"relation":{},"ISSN":["1540-9740","1751-7125"],"issn-type":[{"value":"1540-9740","type":"print"},{"value":"1751-7125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5]]}}}