{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:11:10Z","timestamp":1773886270316,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,2,6]],"date-time":"2007-02-06T00:00:00Z","timestamp":1170720000000},"content-version":"vor","delay-in-days":220,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skinmed"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p> <jats:italic>\n            <jats:bold>Introduction<\/jats:bold>: Helicobacter pylori, a common cause of gastritis and peptic ulcer, has been associated with several extragastrointestinal diseases. Many studies have shown a positive relation between <\/jats:italic>H. <jats:italic>pylori infection and both chronic idiopathic urticaria and atopic dermatitis.<\/jats:italic><\/jats:p><jats:p> <jats:italic>\n            <jats:bold>Methods:<\/jats:bold> The study included 20 patients diagnosed with chronic idiopathic urticaria and 20 with atopic dermatitis. A randomized sample of 20 healthy individuals was selected as a control group. <\/jats:italic>H. <jats:italic>pylori infection was assessed using the C\u2010urea breath test, and anti\u2010<\/jats:italic>H. <jats:italic>pylori IgG antibody titers were determined by enzyme\u2010linked immunosorbent assay.<\/jats:italic><\/jats:p><jats:p> <jats:italic>\n            <jats:bold>Results<\/jats:bold>: In the chronic idiopathic urticaria group, the urea breath test titer was positive in 75% of patients, and anti\u2010IgG antibodies were also detected in 75% of patients. In the atopic dermatitis group, titer was positive in 70% and antibodies were detected in 65% of patients, while in the control group, the urea breath test titer was positive in 55% and antibodies were seen in 20% of patients. This difference was statistically highly significant (<\/jats:italic>p&lt;<jats:italic>0.001) in the case of anti\u2010<\/jats:italic>H. <jats:italic>pylori antibodies in relation to chronic idiopathic urticaria and significant (<\/jats:italic>p&lt;<jats:italic>0.05) in the case of atopic dermatitis.<\/jats:italic><\/jats:p><jats:p> <jats:italic>\n            <jats:bold>Conclusions<\/jats:bold>: These results provide some evidence of a relationship between <\/jats:italic>H. <jats:italic>pylori infection and both chronic idiopathic urticaria and atopic dermatitis. Treatment of infection demonstrated by reduction in C\u2010urea breath test and anti\u2010<\/jats:italic>H. <jats:italic>pylori antibody titers resulted in partial improvement of clinical symptoms in patients with atopic dermatitis.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-9740.2006.04646.x","type":"journal-article","created":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T00:53:03Z","timestamp":1170809583000},"page":"172-176","source":"Crossref","is-referenced-by-count":24,"title":["The Role of <i>Helicobacter pylori<\/i> in Urticaria and Atopic Dermatitis"],"prefix":"10.1111","volume":"5","author":[{"given":"Ibrahim H.","family":"Galadari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Omar","family":"Sheriff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)80005-4"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026677728175"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8780570"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i1.5"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1157\/13052428"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/000155598442746"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00328.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000018088"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.026_c.x"},{"key":"e_1_2_6_11_2","first-page":"827","article-title":"CagA\u2010positive Helicobacter pylori infection may increase the risk of food allergy development","volume":"50","author":"Figura N","year":"1999","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.3.297"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1027\/0838-1925.13.1.23"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)00846-6"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200306000-00009"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200302000-00003"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2000.0817"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.1.8"},{"key":"e_1_2_6_19_2","first-page":"290","article-title":"Serum tumour necrosis factor\u2010alpha is increased in patients with Helicobacter pylori infection and CagA antibodies","volume":"31","author":"Perri F","year":"1999","journal-title":"Ital J Gastroenterol Hepatol"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1081\/IPH-100102563"}],"container-title":["SKINmed: Dermatology for the Clinician"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-9740.2006.04646.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-9740.2006.04646.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T10:33:34Z","timestamp":1695810814000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-9740.2006.04646.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1111\/j.1540-9740.2006.04646.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-9740.2006.04646.x","archive":["Portico"],"relation":{},"ISSN":["1540-9740","1751-7125"],"issn-type":[{"value":"1540-9740","type":"print"},{"value":"1751-7125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}