{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T05:42:36Z","timestamp":1694497356100},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,2,6]],"date-time":"2007-02-06T00:00:00Z","timestamp":1170720000000},"content-version":"vor","delay-in-days":158,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skinmed"],"published-print":{"date-parts":[[2006,9]]},"abstract":"A 65\u2010year\u2010old diabetic Saudi Arabian man taking glibenclamide for 9 years presented with painful reddish patches and plaques involving the palms and soles of 6 months' duration. These lesions started as small faint purple\u2010red macules and gradually increased in number and size. The patient did not seek any medical advice other than for these painful lesions. His medical history was insignificant. On examination, the patient had multiple, discrete, dull red\u2010to\u2010violaceous and tender patches and plaques of variable sizes on both palms and soles (Figure\u20031<\/jats:ext-link> and xFigure\u20032<\/jats:ext-link>). His mucous membranes, scalp, and nails were normal. A systemic clinical examination was unremarkable other than an amputation of the distal phalanx of the left index. Result of routine laboratory investigations including complete blood cell count, liver and renal function tests, and chest x\u2010ray were normal. An HIV test was negative. A punch skin biopsy taken from the left palm showed acanthosis and spongiosis in the epidennis. The dennis showed a large number of dilated, medium\u2010sized capillaries with scanty extravasated red blood cells, marked infiltration of lymphocytes and histiocytes, and a few plasma cells (Figure\u20033<\/jats:ext-link> and Figure\u20034<\/jats:ext-link>). Immunohistochemistry results were positive for CD34 and CD68. Polymerase chain reaction for human herpesvirus 8 was also positive. The treatment options, including cryotherapy and intralesional chemotherapy, were discussed with the patient but, unfortunately, he did not return for follow\u2010up.<\/jats:p> Multiple, discrete, dull red\u2010to\u2010violaceous patches and plaques on both hands<\/jats:italic> <\/jats:p><\/jats:caption>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p> The right foot showing multiple, discrete, dull red\u2010to\u2010violaceous patches and plaques<\/jats:italic> <\/jats:p><\/jats:caption>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p> Punch skin biopsy from the left palm showing a large number of dilated mediumsized capillaries with scanty extravasated red blood cells, marked infiltration of lymphocytes and histiocytes, and a few plasma cells (hemotoxylin and eosin stain; original magnification \u00d720)<\/jats:italic> <\/jats:p><\/jats:caption>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p> A close\u2010up view of the dermis showing a large number of dilated medium\u2010sized capillaries with scanty extravasated red blood cells, marked infiltration of lymphocytes and histiocytes, and a few plasma cells (hemotoxylin and eosin stain; original magnification \u00d740)<\/jats:italic> <\/jats:p><\/jats:caption>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p>","DOI":"10.1111\/j.1540-9740.2006.04662.x","type":"journal-article","created":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T00:53:03Z","timestamp":1170809583000},"page":"248-249","source":"Crossref","is-referenced-by-count":1,"title":["Primary Palmoplantar Kaposi's Sarcoma: An Unusual Presentation"],"prefix":"10.1111","volume":"5","author":[{"given":"Abdullateef A.","family":"Al Zolibani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad A.","family":"Al Robaee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,6]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00747.x"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00746.x"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05359.x"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00845.x"},{"key":"e_1_2_2_6_2","first-page":"107","article-title":"A rare case of Kaposi's sarcoma; 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