{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T17:32:23Z","timestamp":1696959143221},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,2,6]],"date-time":"2007-02-06T00:00:00Z","timestamp":1170720000000},"content-version":"vor","delay-in-days":220,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skinmed"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p>A 21\u2010year\u2010old woman of Romany origin, in the third trimester of her fourth pregnancy, was admitted to the hospital because of a generalized erythematous and pustular eruption and desquamation involving her face, neck, trunk, and extremities. The skin changes were accompanied by fever (100.4\u00b0F [38\u00b0C]) and malaise. The patient was convinced that the dermatitis was induced by the consumption of \u201cspoilt\u201d pork sausage (bad smell, changed taste) approximately 24 hours earlier. Clinical examination revealed a woman with phototype III skin, black eyes, and black hair, in good general health. Widespread, symmetrical, moderately intense erythema and isolated or coalescing targetoid lesions studded with discrete, pinhead\u2010sized, nonfollicular pustules in the center or at the periphery were distributed over her face, trunk, groins, and upper and lower extremities (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f1\">Figures\u20031<\/jats:ext-link>). On the neck and abdomen, lamellar desquamation was observed (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f2\">Figure\u20032<\/jats:ext-link>). Palms, soles, scalp, mucous membranes, hair, and nails were not affected. Nikolsky's sign was negative. The patient complained of very slight skin burning and itching. The pregnancy was proceeding without any complications and her obstetric status was normal. The woman had neither any accompanying diseases, nor previous personal or family history of psoriasis, nor any known allergies. She had taken no systemic medication (not even vitamins). She had three pregnancies; two ended with the delivery of healthy babies and one of them was aborted at her will. Laboratory studies revealed leukocytosis (13.2 \u00d7 10<jats:sup>9<\/jats:sup>\/L), neutrophilia (8 \u00d7 10<jats:sup>9<\/jats:sup>\/L), anemia (hemoglobin, 108 g\/L), and an elevated erythrocyte sedimentation rate (68\u2013110 mm\/h). The results from the following investigations were normal: urinalysis, renal and hepatic function, serum albumin, Ca, Na, K, aspartate aminotransferase titer, cryoprotein, hepatitis B surface antigen, and serum markers for syphilis. Bacterial and fungal cultures of pustular content were sterile. A skin biopsy specimen of lesional skin revealed subcorneal pustules containing leukocytes and necrotic keratinocytes and a mixed perivascular inflammatory infiltrate with isolated eosinophils in the dermis (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f3\">Figure\u20033<\/jats:ext-link>). The patient was treated with systemic methylprednisolone in gradually reduced doses, fluocinonide cream 0.05%, and emollients. As a result, her fever disappeared and her erythema faded. Frequent obstetric examination and cardiotocography were normal and showed no evidence of placental insufficiency. At 40 weeks\u2019 gestation, the patient spontaneously gave birth without any complications to a healthy boy. She was discharged with complete resolution of the skin lesions, preceded by massive desquamation of the epidermis. The 1\u2010year follow\u2010up of the patient revealed no relapses or new pustular eruptions.<\/jats:p><jats:p><jats:fig><jats:caption><jats:p> <jats:italic>Targetoid lesions with pustules and desquamation on the lower extremities<\/jats:italic> <\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:15409740:media:SKM4841:SKM_4841_f1\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p><jats:p><jats:fig><jats:caption><jats:p> <jats:italic>Erythema and desquamation on the trunk<\/jats:italic> <\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:15409740:media:SKM4841:SKM_4841_f2\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p><jats:p><jats:fig><jats:caption><jats:p> <jats:italic>Subcorneal pustule containing leukocytes and necrotic keratinocytes and polymorphic infiltrate in the dermis (hematoxylineosin stain, original magnification \u00d7100)<\/jats:italic> <\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:15409740:media:SKM4841:SKM_4841_f3\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p>","DOI":"10.1111\/j.1540-9740.2006.04841.x","type":"journal-article","created":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T00:53:03Z","timestamp":1170809583000},"page":"199-201","source":"Crossref","is-referenced-by-count":2,"title":["Food\u2010Induced Acute Generalized Exanthematous Pustulosis in a Pregnant Woman"],"prefix":"10.1111","volume":"5","author":[{"given":"Sonya","family":"Valkova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,6]]},"reference":[{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1991.01680080069004"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.028003113.x"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-9740.2004.02570.x"},{"key":"e_1_2_3_5_2","first-page":"612","article-title":"Drugs associated with acute generalized exanthematic pustulosis [in French]","volume":"130","author":"Saissi EH","year":"2003","journal-title":"Ann Dermatol Venereal"},{"key":"e_1_2_3_6_2","first-page":"114","volume-title":"Fisher's Contact Dermatitis","author":"Rietschel RL","year":"1995"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03643.x"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1990.tb01832.x"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200208000-00006"}],"container-title":["SKINmed: Dermatology for the Clinician"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-9740.2006.04841.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-9740.2006.04841.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T10:33:32Z","timestamp":1695810812000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-9740.2006.04841.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1111\/j.1540-9740.2006.04841.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-9740.2006.04841.x","archive":["Portico"],"relation":{},"ISSN":["1540-9740","1751-7125"],"issn-type":[{"value":"1540-9740","type":"print"},{"value":"1751-7125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}