{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T12:10:19Z","timestamp":1697026219101},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,2,6]],"date-time":"2007-02-06T00:00:00Z","timestamp":1170720000000},"content-version":"vor","delay-in-days":67,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skinmed"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>A 56\u2010year\u2010old man presented with a cutaneous lesion on his right hand (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f1\">Figure\u20031<\/jats:ext-link>). Approximately 6 weeks previously, he had traveled to Costa Rica for missionary work. During his travel he used a diethyltoluamide\u2010containing insect repellant, but spent one night in the jungle without a mosquito net. Four weeks after his return, he noted a 3 \u00d7 2.5\u2010cm ulcer with raised edges and surrounding erythema on the dorsum of his right hand. The patient recalled applying insect repellant with his right hand to other exposed areas of his body but was remiss in applying it to the right hand itself. On examination, the patient was noted to have an ulcerated nodule near his right earlobe (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f2\">Figure\u20032<\/jats:ext-link>) and a second 2 \u00d7 1\u2010cm ulcer on the volar aspect of his right wrist (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f3\">Figure\u20033<\/jats:ext-link>). There were no mucocutaneous lesions noted. During the next several weeks, numerous nodules developed in a sporotrichoid pattern on the extensor surface of his right arm (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f4\">Figure\u20034<\/jats:ext-link>). Skin biopsy was performed at the time of initial evaluation and revealed cutaneous leishmaniasis due to <jats:italic>Leishmania panamensis.<\/jats:italic> After discussing the different treatment options, miltefosine was administered orally for 28 days. The patient experienced an excellent response to therapy.<\/jats:p><jats:p><jats:fig><jats:caption><jats:p> <jats:italic>Ulcer, dorsum, right hand.<\/jats:italic> <\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:15409740:media:SKM5028:SKM_5028_f1\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p><jats:p><jats:fig><jats:caption><jats:p> <jats:italic>Eschar, anterior to right ear.<\/jats:italic> <\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:15409740:media:SKM5028:SKM_5028_f2\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p><jats:p><jats:fig><jats:caption><jats:p> <jats:italic>Ulcer, volar surface, right forearm.<\/jats:italic> <\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:15409740:media:SKM5028:SKM_5028_f3\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p><jats:p><jats:fig><jats:caption><jats:p> <jats:italic>Sporotrichoid lesions, right forearm.<\/jats:italic> <\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:15409740:media:SKM5028:SKM_5028_f4\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p>","DOI":"10.1111\/j.1540-9740.2006.05028.x","type":"journal-article","created":{"date-parts":[[2007,2,6]],"date-time":"2007-02-06T23:52:07Z","timestamp":1170805927000},"page":"296-299","source":"Crossref","is-referenced-by-count":2,"title":["Bite the Hand That Sprays You"],"prefix":"10.1111","volume":"5","author":[{"given":"Sameer B.","family":"Ismailjee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack M.","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven D.","family":"Burdette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,6]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"1339","volume-title":"Manson's Tropical Diseases","author":"Dedet JP","year":"2003"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)10178-2"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-005-1363-1"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01677.x"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(88)90400-2"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70492-3"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.00038.x"},{"key":"e_1_2_4_9_2","first-page":"1455","article-title":"Cutaneous leishmaniasis: recognition and treatment","volume":"69","author":"Markle WH","year":"2004","journal-title":"Am Earn Physician"},{"key":"e_1_2_4_10_2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.4269\/ajtmh.1987.36.489","article-title":"Diagnosis of cutaneous and mucocutaneous leishmaniasis in Colombia: a comparison of seven methods","volume":"36","author":"Weigle KA","year":"1987","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021556"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/383321"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/322689"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/430444"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/505217"}],"container-title":["SKINmed: Dermatology for the 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