{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T05:42:38Z","timestamp":1694497358571},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,2,6]],"date-time":"2007-02-06T00:00:00Z","timestamp":1170720000000},"content-version":"vor","delay-in-days":158,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skinmed"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p> <jats:bold>\n            <jats:italic>The rise in incidence of malignant melanoma and the dismal prognosis of late detection emphasize the need for early detection and recognition of the disease. The well\u2010known ABCD method for detection of melanoma has recently been revised by adding an \u201cE\u201d for changes in size, shape, color, crusting, itching, bleeding, and erythema. In an observational study, 8 of 14 (57%) melanoma patients exhibited a particular reddish hue to the skin adjacent to the melanoma, with no distinguishable borders. In another study, vascular endothelial growth factor was positive in biopsy specimens from 3 of 6 (50%) patients with erythema and in 4 of 7 (57%) patients without erythema. Platelet\u2010derived growth factor was positive in all 6 (100%) of the patients with erythema and in 4 of the 7 (57%) without erythema. This erythema can help alert the clinician to the presence of malignant melanoma and serve as a prognostic factor or an indicator of the efficacy of treatment.<\/jats:italic>\n          <\/jats:bold> <\/jats:p>","DOI":"10.1111\/j.1540-9740.2006.05641.x","type":"journal-article","created":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T00:53:03Z","timestamp":1170809583000},"page":"233-237","source":"Crossref","is-referenced-by-count":0,"title":["A Possible Additional Diagnostic Tool for Cutaneous Melanoma"],"prefix":"10.1111","volume":"5","author":[{"given":"Sarah","family":"Brenner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,6]]},"reference":[{"key":"e_1_2_2_2_2","first-page":"917","volume-title":"Fitzpatrick's Dermatology in General Medicine","author":"Langley RGB","year":"2003"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2005.00054.x"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(03)00058-0"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.12.001"},{"key":"e_1_2_2_6_2","doi-asserted-by":"crossref","first-page":"464","DOI":"10.2340\/0001555572464","article-title":"The \u201cred face\u201d\u2014a warning sign of malignant melanoma?","volume":"72","author":"Brenner S","year":"1992","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-9740.2003.02569.x"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.01175.x"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1999.0614"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-199311000-00005"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(20000615)86:6<768::AID-IJC3>3.0.CO;2-E"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)00921-6"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-198510000-00013"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80108-7"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10259"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-419X(98)00015-8"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00089-8"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-1489"}],"container-title":["SKINmed: Dermatology for the Clinician"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-9740.2006.05641.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-9740.2006.05641.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T10:43:34Z","timestamp":1694429014000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-9740.2006.05641.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1540-9740.2006.05641.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-9740.2006.05641.x","archive":["Portico"],"relation":{},"ISSN":["1540-9740","1751-7125"],"issn-type":[{"value":"1540-9740","type":"print"},{"value":"1751-7125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}