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We first derive closed\u2010form expressions for the expected number of tests (efficiency) and misclassification probabilities (sensitivity, specificity, predictive values) for two\u2010dimensional array testing in a heterogeneous population. We then propose two \u201cinformative\u201d array construction techniques which exploit population heterogeneity in ways that can substantially improve testing efficiency when compared to classical approaches that regard the population as homogeneous. Furthermore, a useful byproduct of our methodology is that misclassification probabilities can be estimated on a per\u2010individual basis. We illustrate our new procedures using chlamydia and gonorrhea testing data collected in Nebraska as part of the Infertility Prevention Project.<\/jats:p>","DOI":"10.1111\/j.1541-0420.2011.01726.x","type":"journal-article","created":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T22:23:33Z","timestamp":1325197413000},"page":"793-804","source":"Crossref","is-referenced-by-count":34,"title":["Two\u2010Dimensional Informative Array Testing"],"prefix":"10.1093","volume":"68","author":[{"given":"Christopher S.","family":"McMahan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M.","family":"Tebbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Bilder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,12,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00833.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1198\/jasa.2010.ap09231"},{"key":"e_1_2_9_4_1","unstructured":"Centers for Disease Control and Prevention(2010). 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