{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:13:57Z","timestamp":1770063237285,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,10,3]],"date-time":"2006-10-03T00:00:00Z","timestamp":1159833600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Brain natriuretic peptide or B\u2010type natriuretic peptide (BNP) is a sensitive marker of heart disease. Plasma levels of BNP increase in left ventricular failure and determination of plasma BNP has become a useful tool in the diagnosis of heart failure. Hemodialysis (HD) patients may have elevated plasma levels of BNP, particularly predialysis, that correlate with echocardiographic signs of left ventricular dysfunction. High BNP levels are also a strong predictor of mortality in both nonrenal and HD patients. We studied plasma BNP levels in patients who changed from conventional thrice\u2010weekly dialysis to daily dialysis 6 times a week while maintaining a total weekly time on dialysis of 12\u2003hr. Twelve HD patients, mean age 55 years, had 4\u2003hr of conventional thrice\u2010weekly treatment for 4 weeks. Predialysis and postdialysis blood samples were obtained at the last dialysis. Patients were then dialyzed for 2\u2003hr, 6 times weekly, for 4 weeks (daily dialysis). Again, predialysis and postdialysis blood samples were collected at the last HD. Brain natriuretic peptide plasma concentrations were determined by immunoradiometric assay. Predialysis BNP levels decreased from 194\u00b151\u2003ng\/L (68\u00b119\u2003pmol\/L; mean+SE) during thrice\u2010weekly HD to 113\u00b145\u2003ng\/L (41\u00b118\u2003pmol\/L; p=0.001) after 4 weeks on daily dialysis. With thrice\u2010weekly HD, predialysis BNP levels were higher than postdialysis levels: 120\u00b126\u2003ng\/L (39\u00b18\u2003pmol\/L; p=0.059). With daily dialysis, predialysis BNP levels did not differ significantly from postdialysis levels. Elevated predialysis plasma levels of BNP, considered sensitive and early markers of left ventricular dysfunction, decreased when patients were changed from conventional thrice\u2010weekly HD to daily dialysis maintaining total hours of dialysis per week constant. Given the accumulated evidence that BNP is a biomarker of left ventricular dysfunction and can be used for risk stratification and guidance in pharmacotherapy of heart failure, daily dialysis appears to lead to less cardiac distress.<\/jats:p>","DOI":"10.1111\/j.1542-4758.2006.00136.x","type":"journal-article","created":{"date-parts":[[2006,10,3]],"date-time":"2006-10-03T08:40:27Z","timestamp":1159864827000},"page":"394-398","source":"Crossref","is-referenced-by-count":25,"title":["Daily dialyses decrease plasma levels of brain natriuretic peptide (BNP), a biomarker of left ventricular dysfunction"],"prefix":"10.1111","volume":"10","author":[{"given":"Ingegerd","family":"ODAR\u2010CEDERL\u00d6F","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"BJELLERUP","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"WILLIAMS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher R.","family":"BLAGG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zbylut","family":"TWARDOWSKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"TING","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl M.","family":"KJELLSTRAND","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,3]]},"reference":[{"issue":"1","key":"e_1_2_8_2_2","first-page":"S121","article-title":"Morbidity and mortality","volume":"47","year":"2006","journal-title":"USRDS 2005 Annual Data Report"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v32.pm9820470"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe038233"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115146"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)93126-L"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)06031-5"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02053-5"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2001.113215"},{"key":"e_1_2_8_10_2","first-page":"161","article-title":"Breathing not properly multinational study investigators","volume":"347","author":"Maisel AS","year":"2002","journal-title":"Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0820127"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80903-6"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000013385"},{"key":"e_1_2_8_14_2","first-page":"509","article-title":"Attenuation of compensation of endogenous cardiac natriuretic peptide system in chronic heart failure","volume":"96","author":"Tsutamoto T","year":"1997","journal-title":"Prognostic role of plasma brain natriuretic peptide concentration in patients with chronic symptomatic left ventricular dysfunction"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011053"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000065272"},{"key":"e_1_2_8_17_2","first-page":"1508","article-title":"Creed investigators","volume":"12","author":"Zoccali C","year":"2001","journal-title":"Cardiac natriuretic peptides are related to left ventricular mass and function and predict mortality in dialysis patients"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807303390507"},{"key":"e_1_2_8_19_2","first-page":"222","article-title":"Cardiovasoactive peptides in hemodialysis patients","volume":"7","author":"Odar\u2010Cederlof I","year":"2003","journal-title":"Diagnostic tools and predictors of outcome. 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