{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:01:52Z","timestamp":1759482112697},"reference-count":60,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2006,1,25]],"date-time":"2006-01-25T00:00:00Z","timestamp":1138147200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite several technical advances in dialysis treatment modalities and a better patient care management including correction of anemia, suppression of secondary hyperparathyroidism, lipid and oxidative stress profiles improvement, the morbidity and the mortality of dialysis patients still remain still elevated. Recent prospective interventional trials in hemodialysis (HEMO study and 4D study) were not very conclusive in showing any significant improvement in dialysis patient outcomes. High\u2010efficiency convective therapies, such as online hemodiafiltration (HDF), are claimed to be superior to conventional diffusive hemodialysis (HD) in improving the dialysis efficacy and in reducing intradialytic morbidity and all\u2010cause and cardiovascular mortality in dialysis patients. The aim of this report was, first, to review the evidence\u2010based facts tending to prove the superiority of HDF vs. HD in terms of efficacy and tolerance, and, second, to analyze the needs to prove the clinical superiority of HDF in terms of reducing morbidity and all\u2010cause mortality of dialysis patients. A systematic review of studies comparing HDF and HD has been performed in the microbiological safety of online production, the solute removal capacity of small and medium\u2010size uremic toxins, and its implication in the reduction of the bioactive dialysis system vs. patient interaction. Major planned randomized international studies comparing HDF and HD in terms of morbidity and mortality have been reviewed. To conclude, it is thought that these long\u2010term prospective randomized trials will clarify on a scientific evidence\u2010based level the putative beneficial role of high\u2010efficiency HDF modalities on dialysis patient outcomes.<\/jats:p>","DOI":"10.1111\/j.1542-4758.2006.01183.x","type":"journal-article","created":{"date-parts":[[2006,1,25]],"date-time":"2006-01-25T09:25:42Z","timestamp":1138181142000},"source":"Crossref","is-referenced-by-count":33,"title":["Overview of clinical studies in hemodiafiltration: What do we need now ?"],"prefix":"10.1111","volume":"10","author":[{"given":"Bernard","family":"CANAUD","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"MORENA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"LERAY\u2010MORAGUES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lofti","family":"CHALABI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Paul","family":"CRISTOL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,25]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"3","article-title":"On\u2010line haemodiafiltration","volume":"5","author":"Canaud B","year":"1998","journal-title":"State of the art"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.suppl_5.21"},{"key":"e_1_2_5_4_2","first-page":"32","article-title":"European Renal Association. Section IV. Water and dialysis fluid purity","volume":"7","author":"European Best Practice Guidelines Expert Group on Hemodialysis","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_5_5_2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/oxfordjournals.ndt.a027966","article-title":"On\u2010line haemodiafiltration. Safety and efficacy in long\u2010term clinical practice","volume":"1","author":"Canaud B","year":"2000","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.suppl_5.17"},{"key":"e_1_2_5_7_2","first-page":"1035","article-title":"Comparison of hemodialysis and hemodiafiltration","volume":"41","author":"Kerr PB","year":"1992","journal-title":"A long-term longitudinal study"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v31.pm9428455"},{"key":"e_1_2_5_9_2","first-page":"655","article-title":"Phosphate kinetics during hemodialysis","volume":"61","author":"Spalding EM","year":"2002","journal-title":"Evidence for biphasic regulation"},{"key":"e_1_2_5_10_2","first-page":"152","article-title":"Hemodiafiltration\u2014a new treatment option for hyperphosphatemia in hemodialysis patients","volume":"52","author":"Zehnder C","year":"1999","journal-title":"Clin Nephrol"},{"key":"e_1_2_5_11_2","first-page":"66","article-title":"Comparison of various treatment modes in terms of beta 2\u2010microglobulin removal","volume":"13","author":"Shinzato T","year":"1989","journal-title":"Hemodialysis, hemofiltration, and push\/pull HDF"},{"key":"e_1_2_5_12_2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/oxfordjournals.ndt.a027964","article-title":"On\u2010line haemodiafiltration. Remarkable removal of beta2\u2010microglobulin. Long\u2010term clinical observations","volume":"15","author":"Lornoy W","year":"2000","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.5.1202"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.441"},{"key":"e_1_2_5_15_2","first-page":"2344","article-title":"A comparison of on\u2010line hemodiafiltration and high\u2010flux hemodialysis","volume":"11","author":"Ward RA","year":"2000","journal-title":"A prospective clinical study"},{"key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/oxfordjournals.ndt.a027963","article-title":"On\u2010line haemodiafiltration versus low\u2010flux haemodialysis. A prospective randomized study","volume":"15","author":"Wizemann V","year":"2000","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00236.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0940431"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/15.6.846"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000070694"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.63.s84.40.x"},{"key":"e_1_2_5_22_2","first-page":"1995","article-title":"Diffusive vs. convective therapy","volume":"26","author":"Kellum JA","year":"1998","journal-title":"Effects on mediators of inflammation in patient with severe systemic inflammatory response syndrome"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.5.999"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(03)00747-9"},{"key":"e_1_2_5_25_2","first-page":"1045","article-title":"Plasma levels of advanced glycation end products during haemodialysis, haemodiafiltration and haemofiltration","volume":"17","author":"Gerdemann A","year":"2002","journal-title":"Potential importance of dialysate quality"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00496.x"},{"key":"e_1_2_5_27_2","first-page":"1916","article-title":"Thermal effects and blood pressure response during postdilution hemodiafiltration and hemodialysis","volume":"12","author":"Sande FM","year":"2001","journal-title":"The effect of amount of replacement fluid and dialysate temperature"},{"key":"e_1_2_5_28_2","first-page":"411","article-title":"The achievement of normal homocysteinemia in regular extracorporeal dialysis patients","volume":"17","author":"Gonella M","year":"2004","journal-title":"J Nephrol"},{"key":"e_1_2_5_29_2","first-page":"453","article-title":"Haemodiafiltration in high\u2010cardiovascular\u2010risk patients","volume":"7","author":"Mion M","year":"1992","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_5_30_2","first-page":"414","article-title":"Comparison between hemofiltration and hemodiafiltration in a long\u2010term prospective cross\u2010over study","volume":"17","author":"Altieri P","year":"2004","journal-title":"J Nephrol"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg206"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg1078"},{"key":"e_1_2_5_33_2","first-page":"2360","article-title":"Daily on\u2010line haemodiafiltration","volume":"19","author":"Fischbach M","year":"2004","journal-title":"A pilot trial in children"},{"key":"e_1_2_5_34_2","first-page":"197","article-title":"High\u2010flux hemodiafiltration","volume":"7","author":"Cioni L","year":"1989","journal-title":"5 years experience"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00470.x"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.11.2181"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.07810.x"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.61.s80.21.x"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.434"},{"key":"e_1_2_5_40_2","first-page":"1077","article-title":"Beta 2\u2010microglobulin associated amyloidosis","volume":"52","author":"Schwalbe S","year":"1997","journal-title":"A vanishing complication of long-term hemodialysis?"},{"key":"e_1_2_5_41_2","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1681\/ASN.V591703","article-title":"High\u2010flux dialysis membranes improve lipid profile in chronic hemodialysis patients","volume":"5","author":"Blankestijn PJ","year":"1995","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(03)00747-9"},{"key":"e_1_2_5_43_2","first-page":"230","article-title":"Oxidant stress in hemodialysis patients","volume":"27","author":"Ward RA","year":"2003","journal-title":"What are the determining factors?"},{"key":"e_1_2_5_44_2","first-page":"422","article-title":"Convective and diffusive losses of vitamin C during haemodiafiltration session","volume":"17","author":"Morena M","year":"2002","journal-title":"A contributive factor to oxidative stress in haemodialysis patients"},{"key":"e_1_2_5_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.5.1202"},{"key":"e_1_2_5_46_2","doi-asserted-by":"publisher","DOI":"10.1159\/000063104"},{"key":"e_1_2_5_47_2","first-page":"29","article-title":"Dialysis adequacy and response to erythropoietic agents","volume":"18","author":"Locatelli F","year":"2003","journal-title":"What is the evidence base?"},{"key":"e_1_2_5_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/15.8.1207"},{"key":"e_1_2_5_49_2","unstructured":"CanaudB Bragg\u2010GreshamJL MarshallMR et al. Patients receiving hemodiafiltration or hemofiltration have lower mortality risk than patients receiving HD without fluid replacement in Europe: The Dialysis Outcomes and Practice Patterns Study American Society of Nephrology 2003."},{"key":"e_1_2_5_50_2","first-page":"136","article-title":"Evidence\u2010based medicine in the dialysis unit","volume":"17","author":"Briggs JP.","year":"2004","journal-title":"A few lessons from the USRDS and the NCDS and HEMO trials"},{"key":"e_1_2_5_51_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808273390903"},{"key":"e_1_2_5_52_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021583"},{"key":"e_1_2_5_53_2","first-page":"3251","article-title":"Effects of high\u2010flux hemodialysis on clinical outcomes","volume":"12","author":"Cheung AK","year":"2003","journal-title":"Results of the HEMO study"},{"key":"e_1_2_5_54_2","first-page":"3251","article-title":"Effects of high\u2010flux hemodialysis on clinical outcomes","volume":"12","author":"Cheung AK","year":"2003","journal-title":"Results of the HEMO study"},{"key":"e_1_2_5_55_2","first-page":"1061","article-title":"Dose of dialysis, convection and haemodialysis patients outcome","volume":"18","author":"Locatelli F.","year":"2003","journal-title":"What the HEMO study doesn't tell us: The European viewpoint"},{"key":"e_1_2_5_56_2","article-title":"Randomized controlled trial on the efficacy and safety of atorvastatin in patients with type 2 diabetes on hemodialysis (4D study)","volume":"37","author":"Wanner C","year":"2004","journal-title":"Demographic and baseline characteristics"},{"key":"e_1_2_5_57_2","doi-asserted-by":"publisher","DOI":"10.1159\/000081866"},{"key":"e_1_2_5_58_2","first-page":"50","article-title":"Convection versus diffusion in dialysis","volume":"7","author":"Bolasco P","year":"2003","journal-title":"An Italian prospective multicentre study"},{"key":"e_1_2_5_59_2","unstructured":"BlankensteinPJ BotsML GrootemanMPC et al. Effect of increased convective clearance by on\u2010line hemodiafiltration on all\u2010cause cardiovascular mortality in chronic hemodialysis patients. Project supported by the Dutch Kidney Foudation 2003."},{"key":"e_1_2_5_60_2","first-page":"47","article-title":"Resolving controversies regarding hemodiafiltration versus hemodialysis","volume":"18","author":"Penne EL","year":"2005","journal-title":"The Dutch Convective Transport Study"},{"key":"e_1_2_5_61_2","unstructured":"CanaudB MorenaM JaussonI CristolJP.Clinical tolerance of on\u2010line HDF and impact on morbidity and cardiovascular risk factors in ESRD patients of 65 and more years old. Project supported by a French National Grant from the Health Ministry (PHRC national) 2004."}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1542-4758.2006.01183.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1542-4758.2006.01183.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T13:12:27Z","timestamp":1695820347000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1542-4758.2006.01183.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":60,"journal-issue":{"issue":"s1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1111\/j.1542-4758.2006.01183.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1542-4758.2006.01183.x","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}