{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:56:16Z","timestamp":1761101776860},"reference-count":58,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,11,17]],"date-time":"2006-11-17T00:00:00Z","timestamp":1163721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["sigmapubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Nursing Scholarship"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p> <jats:italic>\n            <jats:bold>Purpose:<\/jats:bold> To (a) provide an overview of chronic dementing conditions; (b) discuss the etiologic and clinical characteristics of Alzheimer disease (AD) and Parkinson disease (PD) within the framework of the family systems genetic illness model; and (c) to explore opportunities to enhance outcomes through the integration of genomics information and technologies into nursing practice.<\/jats:italic> <\/jats:p><jats:p> <jats:italic>\n            <jats:bold>Design:<\/jats:bold> An integrated review of the literature, including the organizing construct of the family systems genetic illness model.<\/jats:italic> <\/jats:p><jats:p> <jats:italic>\n            <jats:bold>Findings:<\/jats:bold> AD and PD are both influenced by genetic and environmental factors; in a small percentage of families, gene mutations are the primary etiologic factor. Genetic testing is an option for some families experiencing early\u2010onset, familial disease. Presymptomatic and diagnostic genetic testing have limited clinical utility for the more common late\u2010onset AD and PD.<\/jats:italic> <\/jats:p><jats:p> <jats:italic>\n            <jats:bold>Conclusions:<\/jats:bold> The current abilities of healthcare professionals to effectively intervene in people with AD and PD are limited by an incomplete understanding of the biologic basis of these diseases. Advances in genomics research and technology are providing the information and tools necessary to understand the molecular basis of these devastating disorders toward the goal of more specific and effective interventions.<\/jats:italic> <\/jats:p>","DOI":"10.1111\/j.1547-5069.2006.00123.x","type":"journal-article","created":{"date-parts":[[2006,11,17]],"date-time":"2006-11-17T10:30:02Z","timestamp":1163759402000},"page":"328-334","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chronic Dementing Conditions, Genomics, and New Opportunities for Nursing Interventions"],"prefix":"10.1111","volume":"38","author":[{"given":"Debra L.","family":"Schutte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezra C.","family":"Holston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,17]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Aarsland D. Bronnick K. Ehrt U. De Deyn P.P. Tekin S. Emre M. et al. (2006).Neuropsychiatric symptoms in patients with PD and dementia: Frequency profile and associated caregiver stress. Retrieved September 26 2006 fromhttp:\/\/jnnp.bmjjournals.com\/cgi\/content\/abstract\/jnnp.2005.083113v1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1527154404272143"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2002.00016.x"},{"key":"e_1_2_5_5_1","volume-title":"Statement on the scope and standards of genetics clinical nursing practice (Pub# 9807ST)","author":"American Nurses Association","year":"1998"},{"key":"e_1_2_5_6_1","volume-title":"DSM\u2010IV: Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gim.0000195884.86201.a0"},{"key":"e_1_2_5_8_1","unstructured":"Bird T.D.(2005).Alzheimer's disease overview. Retrieved December 12 2005 fromhttp:\/\/www.genetests.org"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01626"},{"issue":"3","key":"e_1_2_5_10_1","first-page":"240","article-title":"Neuropsychiatric assessment of Alzheimer's disease and related dementias","volume":"13","author":"Cummings J.L.","year":"2001","journal-title":"Aging (Milano)"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.62.1.10"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000137529.30750.ab"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.2.185"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67889-0"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000049470.00180.07"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.4.594"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/349704a0"},{"key":"e_1_2_5_18_1","first-page":"239","article-title":"Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson's disease","volume":"20","author":"Gorell J.M.","year":"1999","journal-title":"Neurotoxicology"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.1.115"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200110000-00002"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.6.739"},{"issue":"6","key":"e_1_2_5_22_1","first-page":"415","article-title":"The clinical utility of genetic information in the care of people with Alzheimer's disease","volume":"13","author":"Holston E.C.","year":"2004","journal-title":"MEDSURG Nursing: The Journal of Adult Health"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/153331750502000608"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.06.011"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/41.3.334"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/33416"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.1055"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)01077-5"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6823561"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1066"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000110372"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/26652"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7638622"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.6_Suppl_6.S33"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.5.708"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/40.6.663"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg134"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.3928\/0098-9134-20060201-05"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/54.2.M65"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200108000-00002"},{"key":"e_1_2_5_41_1","unstructured":"National Institute of Neurological Disorders and Stroke. (2004).Parkinson's disease: A research planning workshop. Retrieved on July 5 2005 fromhttp:\/\/www.ninds.nih.gov\/news_and_events\/proceedings\/parkinson_workshop_proceeding.htm"},{"key":"e_1_2_5_42_1","volume-title":"2001\u20132002 Progress report on Alzheimer's disease (NIH Publication No. 03\u20105333)","author":"National Institute on Aging","year":"2003"},{"key":"e_1_2_5_43_1","unstructured":"Pankratz N.D. Wojcieszek M.D. &Foroud T.(2004).Parkinson disease overview. Retrieved July 5 2005 fromhttp:\/\/www.genetests.org"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.4065\/77.9.918"},{"issue":"6","key":"e_1_2_5_45_1","first-page":"1034","article-title":"Linkage studies in familial Alzheimer disease: Evidence for chromosome 19 linkage","volume":"48","author":"Pericak\u2010Vance M.A.","year":"1991","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00033-1"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5321.2045"},{"key":"e_1_2_5_48_1","first-page":"435","article-title":"A meta\u2010analysis of Parkinson's disease and exposure to pesticides","volume":"21","author":"Priyadarshi J.A.","year":"2000","journal-title":"Neurotoxicology"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.1.8"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1545-5300.2005.00039.x"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnur.2004.02.012"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1891\/rtnp.17.4.301.53188"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/1099800406289909"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2006.01372.x"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1292-330"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10053"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg068"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1086\/322996"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200304000-00002"}],"container-title":["Journal of Nursing Scholarship"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1547-5069.2006.00123.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/sigmapubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1547-5069.2006.00123.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T05:18:27Z","timestamp":1697001507000},"score":1,"resource":{"primary":{"URL":"https:\/\/sigmapubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1547-5069.2006.00123.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,17]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1547-5069.2006.00123.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1547-5069.2006.00123.x","archive":["Portico"],"relation":{},"ISSN":["1527-6546","1547-5069"],"issn-type":[{"value":"1527-6546","type":"print"},{"value":"1547-5069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,17]]},"assertion":[{"value":"2006-11-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}