{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T01:06:34Z","timestamp":1781744794896,"version":"3.54.5"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,4,3]],"date-time":"2006-04-03T00:00:00Z","timestamp":1144022400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p> <jats:italic>Background:<\/jats:italic> Reversible leukoencephalopathy syndrome (RLS) is an acute neurological syndrome associated with altered mental status and visual disturbances described in patients with sudden elevations in systemic blood pressure and other medical conditions. In this process, neuroimaging studies usually demonstrate diffuse edema involving the subcortical structures of the posterior regions of the brain. Triple H (HHH) therapy is an established treatment for symptomatic vasospasm following subarachnoid hemorrhage (SAH). RLS has not been reported in the scientific literature as a complication of HHH therapy with perfusion computed tomography (CTP) imaging documentation. <jats:italic>Case:<\/jats:italic> A 73\u2010year\u2010old woman developed iatrogenic RLS during HHH therapy for SAH\u2010related vasospasm. The computed tomography (CT) revealed bilateral parieto\u2010occipital hypodensities. The CTP study showed increased cerebral blood volume and blood flow as well as decreased mean transit time in both parietal\u2010occipital regions, which is compatible with vasogenic edema. <jats:italic>Conclusion:<\/jats:italic> The induction of hypertension as part of HHH therapy for SAH\u2010related cerebral vasospasm may result in RLS. Therefore, it should be considered as a potentially reversible cause in the differential diagnosis of neurological deterioration in SAH patients while on HHH therapy. CTP study can offer an alternative for the assessment of this cerebrovascular syndrome.<\/jats:p>","DOI":"10.1111\/j.1552-6569.2006.00031.x","type":"journal-article","created":{"date-parts":[[2009,10,5]],"date-time":"2009-10-05T13:58:49Z","timestamp":1254751129000},"page":"170-175","source":"Crossref","is-referenced-by-count":56,"title":["CT and CT\u2010Perfusion Findings of Reversible Leukoencephalopathy During Triple\u2010H Therapy for Symptomatic Subarachnoid Hemorrhage\u2010Related Vasospasm"],"prefix":"10.1111","volume":"16","author":[{"given":"Katja E.","family":"Wartenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Parra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,4,3]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602223340803"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.77.903.24"},{"key":"e_1_2_5_4_2","first-page":"1199","article-title":"Posterior reversible encephalopathy syndrome: utility of fluid\u2010attenuated inversion recovery MR imaging in the detection of cortical and subcortical lesions","volume":"21","author":"Casey SO","year":"2000","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.159.2.1632361"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00075198-200304000-00006"},{"issue":"1","key":"e_1_2_5_7_2","first-page":"15","article-title":"Epidemiology and pathophysiology of cerebral vasospasm following subarachnoid hemorrhage","volume":"42","author":"Pasqualin A","year":"1998","journal-title":"J Neurosurg Sci"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11936-002-0017-1"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199905000-00097"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.2.431"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0720-048X(02)00359-5"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000058231.08870.1F"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1227\/00006123-198306000-00012","article-title":"Control of hypertension and prophylaxis against vasospasm in cases of subarachnoid hemorrhage: a preliminary report","volume":"12","author":"Rosenwasser RH","year":"1983","journal-title":"Neurosurgery"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1993.78.3.0423"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365517209081099"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1552-6569.2006.00031.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1552-6569.2006.00031.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T02:37:04Z","timestamp":1696991824000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1552-6569.2006.00031.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1111\/j.1552-6569.2006.00031.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1552-6569.2006.00031.x","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4]]}}}