{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:27:14Z","timestamp":1791876434874,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,9,30]],"date-time":"2008-09-30T00:00:00Z","timestamp":1222732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:sec><jats:title>ABSTRACT<\/jats:title><\/jats:sec><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p> <jats:bold>The distinguishing feature in Heidenhain variant Creutzfeldt\u2010Jakob disease (HvCJD) is the presence of visual symptoms preceding the appearance of other clinical manifestations. The purpose of this report is to describe the broad range of visual symptomatology in a patient with HvCJD.<\/jats:bold> <\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p> <jats:bold>The authors describe the clinical, neuroimaging, and EEG features of a 51\u2010year\u2010old man with progressive visual symptoms that were most likely due to HvCJD. Migraine and epilepsy were initial diagnostic considerations.<\/jats:bold> <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> <jats:bold>Our patient presented with progressive visual decline and superimposed spells of visual dysfunction that had complex characteristics. Evolution of an abnormal signal in the parieto\u2010occipital cortex on diffusion weighted MRI, changes on EEG, and clinical course were consistent with HvCJD.<\/jats:bold> <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p> <jats:bold>HvCJD should be considered in all patients who present with unexplained visual phenomena. A remarkable spectrum of visual disturbances can be seen. Close follow\u2010up as well as serial MRI and EEG can help clarify the underlying disease process. Diffusion\u2010weighted and FLAIR sequences should be included in the MRI protocol.<\/jats:bold> <\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1552-6569.2008.00294.x","type":"journal-article","created":{"date-parts":[[2009,10,5]],"date-time":"2009-10-05T15:40:31Z","timestamp":1254757231000},"page":"283-287","source":"Crossref","is-referenced-by-count":11,"title":["Visual Symptoms in the Heidenhain Variant of Creutzfeldt\u2010Jakob Disease"],"prefix":"10.1111","volume":"19","author":[{"given":"Jason R.","family":"Cornelius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Boes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gena","family":"Ghearing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline A.","family":"Leavitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,6,22]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712173172505"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.17.030194.001523"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410350404"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410350504"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004399900124"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00226-3"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.6.811"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02892896"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.17.2.129"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.1.55"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.074856"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-200106000-00008"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-3787(05)85093-3"},{"key":"e_1_2_5_15_2","first-page":"CS9","article-title":"Atypical features of dementia in a patient with Creutzfeldt\u2010Jakob disease","volume":"13","author":"Pachalska M","year":"2007","journal-title":"Med Sci Monitor"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000208487.18608.41"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00145-8"},{"key":"e_1_2_5_18_2","first-page":"242","article-title":"Palinopsia as a presenting manifestation of Creutzfeldt\u2010Jakob disease","volume":"9","author":"Purvin V","year":"1989","journal-title":"J Clin Neuroophthalmol"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)71237-1"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2004000200029"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000228224.35678.60"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-200109000-00006"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1552-6569.2008.00294.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1552-6569.2008.00294.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T14:47:41Z","timestamp":1697035661000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1552-6569.2008.00294.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,22]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["10.1111\/j.1552-6569.2008.00294.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1552-6569.2008.00294.x","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,22]]}}}