{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:59:49Z","timestamp":1778659189602,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T00:00:00Z","timestamp":1294704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:sec><jats:title>ABSTRACT<\/jats:title><\/jats:sec><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>We used L\u2010[1\u2013<jats:sup>11<\/jats:sup>C]leucine (LEU) positron emission tomography (PET) to measure amino acid uptake in children with Sturge\u2010Weber syndrome (SWS), and to relate amino acid uptake measures with glucose metabolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>LEU and 2\u2010deoxy\u20102[<jats:sup>18<\/jats:sup>F]fluoro\u2010D\u2010glucose (FDG) PET were performed in 7 children (age: 5\u00a0months\u201013 years) with unilateral SWS. Asymmetries of LEU uptake in the posterior brain region, underlying the angioma and in frontal cortex, were measured and correlated with glucose hypometabolism. Kinetic analysis of LEU uptake was performed in 4 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Increased LEU standard uptake value (SUV, mean: 15.1%) was found in the angioma region in 6 patients, and smaller increases in LEU SUV (11.5%) were seen in frontal cortex in 4 of the 6 patients, despite normal glucose metabolism in frontal regions. High LEU SUV was due to both increased tracer transport (3\/4 patients) and high protein synthesis rates (2\/4). FDG SUV asymmetries in the angioma region were inversely related to LEU SUV asymmetries (<jats:italic>r<\/jats:italic>=\u2013.83, <jats:italic>P<\/jats:italic>= .042).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Increased amino acid uptake in the angioma region and also in less affected frontal regions may provide a marker of pathological mechanisms contributing to chronic brain damage in children with SWS. J Neuroimaging 2012;22:177\u2010183.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1552-6569.2010.00565.x","type":"journal-article","created":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T21:19:44Z","timestamp":1294780784000},"page":"177-183","source":"Crossref","is-referenced-by-count":4,"title":["Increased L\u2010[1\u2013<sup>11<\/sup>C] Leucine Uptake in the Leptomeningeal Angioma of Sturge\u2010Weber Syndrome: A PET Study"],"prefix":"10.1111","volume":"22","author":[{"given":"B\u00e1lint","family":"Alkonyi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry T.","family":"Chugani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otto","family":"Muzik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane C.","family":"Chugani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senthil K.","family":"Sundaram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Kupsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos E.","family":"Batista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba","family":"Juh\u00e1sz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1148\/101.1.111"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20627"},{"key":"e_1_2_6_4_2","first-page":"27","volume-title":"Sturge\u2010Weber Syndrome","author":"Roach E","year":"1999"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/08830738030180080701"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/nen.0b013e31802d9011"},{"issue":"12","key":"e_1_2_6_7_2","first-page":"119","article-title":"Endothelial cell proliferation and angiogenesis in Sturge\u2010Weber syndrome","volume":"64","author":"Batista C","year":"2008","journal-title":"Ann Neurol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00686879"},{"key":"e_1_2_6_9_2","first-page":"900","article-title":"Multimodality imaging of cortical and white matter abnormalities in Sturge\u2010Weber syndrome","volume":"28","author":"Juh\u00e1sz C","year":"2007","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e32832ee93b"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.107.045930"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:NEON.0000033384.43417.82"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1008"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.43"},{"key":"e_1_2_6_15_2","first-page":"1787","article-title":"Quantification of protein synthesis in the human brain using L\u2010[1\u201311C]\u2010leucine PET: incorporation of factors for large neutral amino acids in plasma and for amino acids recycled from tissue","volume":"47","author":"Sundaram SK","year":"2006","journal-title":"J Nucl Med"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2007.02.001"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.2.189"},{"key":"e_1_2_6_18_2","first-page":"S189","article-title":"Facile synthesis of L\u2010[1\u201311C]leucine as a PET radiotracer for the measurement of cerebral protein synthesis","volume":"48","author":"Mu F","year":"2005","journal-title":"J Labelled Compds Radiopharm"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.01.016"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1983.1"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.07.083"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-009-0225-0"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80790-5"},{"key":"e_1_2_6_24_2","first-page":"23","article-title":"Light microscopy and ultrastructural studies of Sturge\u2010Weber disease","volume":"9","author":"Di Trapani G","year":"1982","journal-title":"Childs Brain"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199710000-00020"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.43.461"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-007-0115-2"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0303-8467(95)00067-T"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600199"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(95)00117-K"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-005-0045-7"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(04)70251-4"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02304.x"},{"key":"e_1_2_6_34_2","first-page":"974","article-title":"Carbon\u201011\u2010methionine PET in focal cortical dysplasia: a comparison with fluorine\u201018\u2010FDG PET and technetium\u201099m\u2010ECD SPECT","volume":"39","author":"Sasaki M","year":"1998","journal-title":"J Nucl Med"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1552-6569.2010.00565.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1552-6569.2010.00565.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T02:27:21Z","timestamp":1698632841000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1552-6569.2010.00565.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,11]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1111\/j.1552-6569.2010.00565.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1552-6569.2010.00565.x","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,11]]}}}