{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:34:55Z","timestamp":1761597295671},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,6,23]],"date-time":"2011-06-23T00:00:00Z","timestamp":1308787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec><jats:title>ABSTRACT<\/jats:title><\/jats:sec><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p><jats:bold>We attempt to evaluate objectively the regional cerebral blood flow (rCBF) changes during long\u2010term donepezil therapy and the relationship between the clinical response and rCBF change in patients with Alzheimer's disease (AD).<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>PATIENTS AND METHODS<\/jats:title><jats:p><jats:bold>Thirty\u2010one patients with mild\u2010to\u2010moderate AD (11 men, 20 female; mean age, 76.2 \u00b1 6.7 years) were treated with donepezil and underwent brain perfusion single\u2010photon emission computed tomography (SPECT) twice with an interval of 24.5 \u00b1 4.2 months. The rCBF was calculated using 3\u2010dimensional stereotaxic region of interest template, a fully automated each region of interest technique. We compared the differences in rCBF between baseline and follow\u2010up SPECT studies. Moreover, all patients were divided into stabilized (<jats:italic>n<\/jats:italic>= 14) and nonstabilized subgroups (<jats:italic>n<\/jats:italic>= 17) based on Mini\u2010Mental State Examination (MMSE) score changes and the changes in rCBF were compared between two subgroups.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p><jats:bold>The mean MMSE score significantly decreased from 20.7 \u00b1 4.6 at baseline to 16.5 \u00b1 6.5 after 2 years. The mean rCBF significantly decreased in the widespread brain regions between the baseline and follow\u2010up SPECT studies. The nonstabilized subgroup showed a significant decrease in rCBF of the parietal and temporal segments compared to the stabilized subgroup.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p><jats:bold>The progression of cognitive deterioration may be related to rCBF affected by the neuropathologic changes of AD.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1552-6569.2011.00612.x","type":"journal-article","created":{"date-parts":[[2011,6,25]],"date-time":"2011-06-25T19:46:51Z","timestamp":1309031211000},"page":"299-304","source":"Crossref","is-referenced-by-count":15,"title":["Evaluation of the Regional Cerebral Blood Flow Changes during Long\u2010Term Donepezil Therapy in Patients with Alzheimer's Disease Using 3DSRT"],"prefix":"10.1111","volume":"22","author":[{"given":"Noriyuki","family":"Kimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihide","family":"Kumamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruaki","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Hanaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuki","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,6,23]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"S10","article-title":"Incidence of dementia and major subtypes in Europe: a collaborative study of population\u2010based cohorts. 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