{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:02:20Z","timestamp":1787014940609,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,2,3]],"date-time":"2012-02-03T00:00:00Z","timestamp":1328227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2014,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n BACKGROUND<\/jats:title>\n Human T\u2010cell lymphotropic virus type I (HTLV\u2010I)\u2010associated myelopathy\/tropical spastic paraparesis (HAM\/TSP) is a disabling neurological disorder characterized by inflammatory changes in the spinal cord. We used a semiautomatic technique to quantify spinal cord volume from 3\u2010dimensional MR images of patients with HAM\/TSP.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n \n Five patients and 5 matched healthy volunteers (HVs) underwent MRI of the cervical and thoracic spinal cord at 1.5 T. Quantification of the spinal cord volume was obtained from 3\u2010dimensional MR images using a semiautomatic technique based on level sets. An unpaired\n t<\/jats:italic>\n \u2010test was used to assess statistical significance.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Significant differences were found between mean spinal cord volume of HVs and HAM\/TSP patients. The thoracic spinal cord volume was 14,050 \u00b1 981 mm\n 3<\/jats:sup>\n for HVs and 8,774 \u00b1 2,218 mm\n 3<\/jats:sup>\n for HAM\/TSP patients (\n P<\/jats:italic>\n = .0079), a reduction of 38%. The cervical spinal cord volume was 9,721 \u00b1 797 mm\n 3<\/jats:sup>\n for HVs and 6,589 \u00b1 897 mm\n 3<\/jats:sup>\n for HAM\/TSP patients (\n P<\/jats:italic>\n = .0079), a reduction of 32%. These results suggest that atrophy is evident throughout the spinal cord not routinely quantified.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n Semiautomatic spinal cord volume quantification is a sensitive technique for quantifying the extent of spinal cord involvement in HAM\/TSP.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/j.1552-6569.2011.00648.x","type":"journal-article","created":{"date-parts":[[2012,2,3]],"date-time":"2012-02-03T12:05:13Z","timestamp":1328270713000},"page":"74-78","source":"Crossref","is-referenced-by-count":14,"title":["HTLV\u2010I\u2010Associated Myelopathy\/Tropical Spastic Paraparesis: Semiautomatic Quantification of Spinal Cord Atrophy from 3\u2010Dimensional MR Images"],"prefix":"10.1111","volume":"24","author":[{"given":"Iordanis E.","family":"Evangelou","sequence":"first","affiliation":[{"name":"Neuroimmunology Branch National Institute of Neurological Disorders and Stroke, National Institutes of Health Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raya","family":"Massoud","sequence":"additional","affiliation":[{"name":"Neuroimmunology Branch National Institute of Neurological Disorders and Stroke, National Institutes of Health Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Neuroimmunology Branch National Institute of Neurological Disorders and Stroke, National Institutes of Health Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000096011.92542.DA"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(90)90060-Z"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2008.03.008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2007.0077"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/13550280600941665"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.47.1284"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000054813"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2006.22.931"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000140496.03342.BC"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/13550280701258431"},{"key":"e_1_2_6_12_1","article-title":"A novel quantification method for cervical spinal cord volume in multiple sclerosis patients from 3D magnetic resonance images","author":"Evangelou IE GA","year":"2008","journal-title":"American Academy of Neurology Annual Meeting, Chicago"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/13550289809114225"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1552-6569.2011.00648.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1552-6569.2011.00648.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T11:26:13Z","timestamp":1696159573000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1552-6569.2011.00648.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,3]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/j.1552-6569.2011.00648.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1552-6569.2011.00648.x","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,3]]}}}