{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:57:37Z","timestamp":1791557857726,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,23]],"date-time":"2012-01-23T00:00:00Z","timestamp":1327276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>Previous studies have found gray matter alterations in the cerebellum and in the visual system in both adults and adolescents with schizophrenia. The present study was conducted to investigate whether white matter tracts associated with these regions are also affected in the early stages of the disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Using a 1.5 Tesla magnetic resonance imaging (MRI) scanner and fiber tracking, the optic radiations and the middle cerebellar peduncles were examined in 13 adolescents with first\u2010admission schizophrenia and 13 healthy controls matched for age, gender, school type, and handedness.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Patients with schizophrenia displayed significantly decreased fractional anisotropy in the optic radiations, but no differences in the middle cerebellar peduncles compared to healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Our findings of altered fiber integrity in the optic radiations in adolescents with schizophrenia are in line with gray matter alterations in the visual cortices previously reported in the same sample and are in accordance with other studies that found decreased fractional anisotropy in these regions. These findings support the view that the visual system plays an important role in the pathogenesis of schizophrenia and may enhance our understanding of associations between the visual cortex and symptoms of the disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1552-6569.2011.00668.x","type":"journal-article","created":{"date-parts":[[2012,1,23]],"date-time":"2012-01-23T18:39:48Z","timestamp":1327343988000},"page":"111-116","source":"Crossref","is-referenced-by-count":13,"title":["The Optic Radiation and the Cerebellar Peduncles in Adolescents with First\u2010Admission Schizophrenia \u2014A Diffusion Tensor Imaging Study"],"prefix":"10.1111","volume":"24","author":[{"given":"Romy","family":"Henze","sequence":"first","affiliation":[{"name":"Section Disorders of Personality Development Department of Child and Adolescent Psychiatry Center for Psychosocial Medicine University of Heidelberg  Germany"},{"name":"the Section Quantitative Imaging\u2010based Disease Characterization Department of Radiology German Cancer Research Center Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romuald","family":"Brunner","sequence":"additional","affiliation":[{"name":"Section Disorders of Personality Development Department of Child and Adolescent Psychiatry Center for Psychosocial Medicine University of Heidelberg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Thiemann","sequence":"additional","affiliation":[{"name":"Section Disorders of Personality Development Department of Child and Adolescent Psychiatry Center for Psychosocial Medicine University of Heidelberg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Parzer","sequence":"additional","affiliation":[{"name":"Section Disorders of Personality Development Department of Child and Adolescent Psychiatry Center for Psychosocial Medicine University of Heidelberg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Klein","sequence":"additional","affiliation":[{"name":"Fraunhofer MEVIS  Bremen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Resch","sequence":"additional","affiliation":[{"name":"Section Disorders of Personality Development Department of Child and Adolescent Psychiatry Center for Psychosocial Medicine University of Heidelberg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram","family":"Stieltjes","sequence":"additional","affiliation":[{"name":"the Section Quantitative Imaging\u2010based Disease Characterization Department of Radiology German Cancer Research Center Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2010.00504.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.01.027"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2002.00353.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1076\/neur.9.5.436.16557"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1176\/ajp.2006.163.11.2011","article-title":"Visual white matter integrity in schizophrenia","volume":"163","author":"Butler PD","year":"2006","journal-title":"Am J Psychiatry"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm184"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.01.015"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.12.082"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.01.003"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1999.0458"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2006.09.009"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2005.01.020"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.03.041"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.05.021"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000079101"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2006.05.014"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000195664.15090.46"},{"key":"e_1_2_6_19_1","volume-title":"The ICD\u201010 Classification of Mental and Behavioural Disorders","author":"WHO","year":"1992"},{"key":"e_1_2_6_20_1","unstructured":"DelmoC WeiffenbachO GabrielM PoustkaF.Kiddie\u2010Sads\u2010Present and lifetime version (K\u2010SADS\u2010PL). 3. Auflage der Deutschen Forschungsversion. Frankfurt am Main: Klinik f\u00fcr Psychiatrie und Psychotherapie des Kindes\u2010 und Jugendalters der Universit\u00e4t Frankfurt 2000."},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200010000-00002"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"e_1_2_6_23_1","volume-title":"Stata Statistical Software: Release 11","author":"StataCorp","year":"2009"},{"key":"e_1_2_6_24_1","unstructured":"WeilerF RexiliusJ KleinJ et al.NeuroQLab\u2014a software assistant for neurosurgical planning and quantitative image analysis. Lecture Notes in Informatics (LNI) Informatik 2009 2nd Workshop on Software Assistants in Medicine.2009."},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp126"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.02.013"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20033"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.12.2198"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.04.016"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1552-6569.2011.00668.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1552-6569.2011.00668.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T20:41:28Z","timestamp":1696279288000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1552-6569.2011.00668.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,23]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/j.1552-6569.2011.00668.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1552-6569.2011.00668.x","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,23]]}}}